2 documents found, page 1 of 1
Obesity impairs resistance to Leishmania major infection in C57BL/6 mice.
Martins, Vinicius Dantas; Campos, Franciele Carolina Silva; Moreira, Felipe Caixeta; Carneiro, Matheus Batista Heitor; Goes, Grazielle RibeiroAn association between increased susceptibility to infectious diseases and obesity has been described as a result of impaired immunity in obese individuals. It is not clear whether a similar linkage can be drawn between obesity and parasitic diseases. To evaluate the effect of obesity in the immune response to cutaneous Leishmania major infection, we studied the ability of C57BL/6 mice fed a hypercaloric diet (...
Short-term protection conferred by Leishvacin® against experimental Leishmania ...
Carneiro, Matheus Batista Heitor; Sousa, Louisa Maria de Andrade e; Vaz, Leonardo Gomes; Santos, Liliane Martins dos; Vilela, LucianoTo date, there is no vaccine available against human leishmaniasis. Although some vaccination protocols can induce immunity in murine models, they fail to induce protection in humans. The reasons for that remain unclear. The aimof the present study was to characterize the changes in the pattern of the immune response during subcutaneous vaccination with Leishvacin® in mice. We also investigated whether IFN-γ an...