22 documents found, page 1 of 3
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistan...
Peltola, Jukka; Colon, Albert J.; Pimentel, José; Coenen, Volker A.; Gil-Nagel, Antonio; Gonçalves Ferreira, António; Lehtimäki, Kai; Ryvlin, PhilippeBackground and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therap...
Pain modulation from the Locus Coeruleus in a model of hydrocephalus: searching...
Louçano, Marta; Oliveira, Joana; Martins, Isabel; Vaz, Rui; Tavares, IsauraPain transmission at the spinal cord is modulated by noradrenaline (NA)-mediated actions that arise from supraspinal areas. We studied the locus coeruleus (LC) to evaluate the expression of the cathecolamine-synthetizing enzyme tyrosine hydroxylase (TH) and search for local oxidative stress and possible consequences in descending pain modulation in a model of hydrocephalus, a disease characterized by enlargemen...
Natural history of familial cerebral cavernous malformation syndrome in childre...
Geraldo, Ana Filipa; Alves, Cesar Augusto P. F.; Luis, Aysha; Tortora, Domenico; Guimarães, Joana; Abreu, Daisy; Reimão, Sofia; Pavanello, MarcoPurpose: There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors. Methods: We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric...
Assessment of food claims and nutritional quality on baby foods
Matias, Filipa; Vaz, Rui; Assunção, Ricardo; Santos, Mariana; Castanheira, IsabelIntroduction: As the use of commercially available complementary foods (CACFs) has increased, it became crucial that appropriate infant feeding is protected and consumers are not mislead by statements about the composition of the product or its nutrition or health related properties. WHO published a report which proposed criteria for identifying products appropriate for promotion for infants and young children ...
Avaliação do perfil nutricional e da rotulagem de alimentos comercializados par...
Matias, Filipa; Vaz, Rui; Assunção, Ricardo; Santos, Mariana; Castanheira, IsabelUma nutrição saudável na infância é fundamental para o normal crescimento e desenvolvimento do bebé. Incentivar as crianças a consumir alimentos saudáveis, através de uma oferta repetida e positiva de novos alimentos, bem como limitar a sua exposição a alimentos considerados não saudáveis, podem evitar a preferências por alimentos e bebidas muito doces, contribuindo para o desenvolvimento de bons hábitos alimen...
iHandU: A Novel Quantitative Wrist Rigidity Evaluation Device for Deep Brain St...
Múrias Lopes, Elodie; Vilas-Boas, Maria do Carmo; Dias, Duarte; Rosas, Maria José; Vaz, Rui; Silva Cunha, João PauloDeep brain stimulation (DBS) surgery is the gold standard therapeutic intervention in Parkinson's disease (PD) with motor complications, notwithstanding drug therapy. In the intraoperative evaluation of DBS's efficacy, neurologists impose a passive wrist flexion movement and qualitatively describe the perceived decrease in rigidity under different stimulation parameters and electrode positions. To tackle this s...
Glioblastoma: is there any blood biomarker with true clinical relevance?
Linhares, Paulo; Carvalho, Bruno; Vaz, Rui; Costa, Bruno M.Glioblastoma (GBM) is the most frequent malignant primary brain tumor in adults, characterized by a highly aggressive, inflammatory and angiogenic phenotype. It is a remarkably heterogeneous tumor at several levels, including histopathologically, radiographically and genetically. The 2016 update of the WHO Classification of Tumours of the Central Nervous System highlighted molecular parameters as paramount feat...
Serum lactate levels are associated with glioma malignancy grade
Branco, Mariana; Linhares, Paulo; Carvalho, Bruno; Santos, Patrícia; Costa, Bruno Marques; Vaz, RuiObjective Recent studies have suggested that high grade gliomas are associated with elevated serum lactate concentrations. The aim of the present study is to assess these findings in a sample of patients. Patients and methods We reviewed the anesthetic charts of patients with low-grade and high-grade glioma who underwent resection surgery and collected serum lactate concentration before tumor resection, as well...
Teor de fibra alimentar num grupo de alimentos representativos da alimentação m...
Vaz, Rui; Matias, Filipa; Bento, A. Cristina; Tavares, Nelson; Santos, Mariana; Castanheira, IsabelIntrodução: O padrão alimentar mediterrânico é considerado modelo alimentar de referência a nível mundial para a manutenção da saúde e prevenção da doença. A alimentação mediterrânica é caracterizada pelo predomínio dos produtos vegetais, entre estes a fruta, os produtos hortícolas, cereais, frutos oleaginosos e leguminosas, e pelo consumo de azeite como principal fonte de gordura. A fibra alimentar é constituí...
Can We Assess the Success of Surgery for Degenerative Spinal Diseases Using Pat...
Rodrigues, Ricardo; Silva, Pedro Santos; Cunha, Marisa; Vaz, Rui; Pereira, PauloBackground: Patients' recall of their preoperative status is seldom used to assess surgical outcomes because of concerns of inaccuracy and bias. Objective: The present study aims to measure the significance of this recall bias and its repercussion on patients' recollection of their preoperative status. Methods: Patients submitted to surgery due to degenerative spine diseases during the period of one year (n=198...