5 documents found, page 1 of 1
Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 ris...
Kirsten, Holger; Petit-Teixeira, Elisabeth; Scholz, Markus; Hasenclever, Dirk; Hantmann, Helene; Heider, Dirk; Wagner, Ulf; Sack, UlrichIntroduction The gene MICA encodes the protein major histocompatibility complex class I polypeptide-related sequence A. It is expressed in synovium of patients with rheumatoid arthritis (RA) and its implication in autoimmunity is discussed. We analyzed the association of genetic variants of MICA with susceptibility to RA. Methods Initially, 300 French Caucasian individuals belonging to 100 RA trio families were...
Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheu...
Teixeira, Vítor; Pierlot, Céline; Migliorini, Paola; Balsa, Alejandro; Westhovens, René; Barrera, Pilar; Alves, Helena; Vaz, Carlos; Fernandes, ManuelaIntroduction A candidate gene approach, in a large case–control association study in the Dutch population, has shown that a 480 kb block on chromosome 4q27 encompassing KIAA1109/Tenr/IL2/ IL21 genes is associated with rheumatoid arthritis. Compared with case–control association studies, family-based studies have the added advantage of controlling potential differences in population structure. Therefore, our aim...
Transcriptome Analysis Describing New Immunity and Defense Genes in Peripheral ...
Teixeira, Vitor Hugo; Olaso, Robert; Martin-Magniette, Marie-Laure; Lasbleiz, Sandra; Jacq, Laurent; Oliveira, Catarina Resende; Hilliquin, PascalBackground: Large-scale gene expression profiling of peripheral blood mononuclear cells from Rheumatoid Arthritis (RA) patients could provide a molecular description that reflects the contribution of diverse cellular responses associated with this disease. The aim of our study was to identify peripheral blood gene expression profiles for RA patients, using Illumina technology, to gain insights into RA molecular...
The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the Eur...
Jacq, Laurent; Garnier, Sophie; Dieudé, Philippe; Michou, Laëtitia; Pierlot, Céline; Migliorini, Paola; Balsa, Alejandro; Westhovens, RenéThe integrin alpha(v)beta3, whose alpha(v) subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide p...
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French...
Jacq, Laurent; Teixeira, Vitor; Garnier, Sophie; Michou, Laëtitia; Dieudé, Philippe; Rocha, Dominique; Pierlot, Céline; Lemaire, IsabelleAbstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three sing...