16 documents found, page 1 of 2
The Stress Response to Surgery and Postoperative Delirium: Evidence of Hypothal...
Cerejeira, J; Batista, P; Nogueira, V; Vaz-Serra, A; Mukaetova-Ladinska, EBIntroduction: The aim of this study is to determine whether postoperative delirium is associated with dysregulation of hypothalamic—pituitary—adrenal and growth hormone/insulin-like growth factor 1 (GH/IGF-1) responses following acute systemic inflammation. Methods: Plasma levels of cortisol, IGF-1, C-reactive protein, interleukin (IL)-6, IL-8, and IL-10 were measured before and after surgery in 101 patients 60...
The Cholinergic System and Inflammation: Common Pathways in Delirium Pathophysi...
Cerejeira, J; Nogueira, V; Luís, P; Vaz-Serra, A; Mukaetova-Ladinska, EBOBJECTIVES: To investigate whether delirium is associated with an unbalanced inflammatory response or a dysfunctional interaction between the cholinergic and immune systems. DESIGN: Cohort observational study. SETTING: General hospital orthopedic ward. PARTICIPANTS: One hundred one individuals aged 60 and older with no previous cognitive impairment undergoing elective arthroplasty. MEASUREMENTS: Incidence of po...
Low preoperative plasma cholinesterase activity as a risk marker of postoperati...
Cerejeira, J; Batista, P; Nogueira, V; Vaz-Serra, A; Mukaetova-Ladinska, EBBACKGROUND: delirium is a frequent neuropsychiatric syndrome affecting medical and surgical elderly patients. Cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities are suppressed in patients with delirium. In this cohort study, we investigated whether these changes emerge during delirium or whether they are ...
The neuroinflammatory hypothesis of delirium
Cerejeira, J; Firmino, H; Vaz-Serra, A; Mukaetova-Ladinska, EBDelirium is a neuropsychiatric syndrome characterized by a sudden and global impairment in consciousness, attention and cognition. It is particularly frequent in elderly subjects with medical or surgical conditions and is associated with short- and long-term adverse outcomes. The pathophysiology of delirium remains poorly understood as it involves complex multi-factorial dynamic interactions between a diversity...
The Portuguese version of Mini-Tinnitus Questionnaire: brief screening test for...
Cerejeira, R; Cerejeira, J; Paiva, S; Gonçalves, P; Firmino, H; Quartilho, MJ; Vaz-Serra, A; Paiva, AHYPOTHESIS: The Portuguese version of Mini-Tinnitus Questionnaire (Mini-TQ) is as valid as the English version to assess tinnitus-associated distress in the Portuguese-speaking population. BACKGROUND: Tinnitus is a major symptom in ENT practice affecting subjects in all demographic groups. Our objective is to validate a Portuguese version of Mini-TQ (Mini-TQ-pv) to be used in clinical practice and research. MET...
Estudo psicométricos do instrumento de avaliação da qualidade de vida da Organi...
Vaz-Serra, A; Canavarro, MC; Simões, MR; Pereira, M; Gameiro, S; Quartilho, MJ; Rijo, D; Carona, C; Paredes, T
Estudo clínico, multicêntrico, aberto, comparativo, sobre eficácia e a seguranç...
Vaz-Serra, A; Firmino, H; Albuquerque, A; Ferreira, L; Sousa, P; Vieira, CR; Figueira, ML
Auto-conceito, coping e ideias de suicídio
Vaz-Serra, A; Pocinho, F
A vulnerabilidade ao stress
Vaz-Serra, A
Construção de uma escala para avaliar a vulnerabilidade ao Stress: a 23 GVS
Vaz-Serra, A