12 documents found, page 1 of 2
Ética e diversidade geracional: (des)encontros?
Gonçalves, Helena; Universidade Católica Portuguesa; Costa, Helena Gil da; Universidade Católica PortuguesaEste é o segundo livro da Coleção do Fórum de Ética da UCP Editora, que integra as obras publicadas no contexto do Estudo Anual do Fórum de Ética da Católica Porto Business School. Trata-se de um livro pensado como um laboratório de experiência em pensamento, como espaço de leitura crítica e ferramenta para promover a reflexão ética nas organizações. "Ética e Diversidade Geracional: (Des)Encontros?" é "um convi...
The impact of daylight‐saving time (DST) on patients with delayed sleep‐wake ph...
Reis, Cátia; Pilz, Luísa K.; Kramer, Achim; Lopes, Luísa V.; Paiva, Teresa; Roenneberg, TillDue to time zones, sun time and local time rarely match. The difference between local and sun time, which we designate by Solar Jet Lag (SoJL), depends on location within a time zone and can range from zero to several hours. Daylight Saving Time (DST) simply adds one hour to SoJL, independent of location. We hypothesized that the impact of DST, is particularly problematic in patients with Delayed Sleep-Wake Pha...
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and l...
Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; Papegaey, AnthonyCaffeine is the most consumed psychoactive substance worldwide. Strikingly, molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal-omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus, at the...
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors inter...
Temido Ferreira, Mariana; Ferreira, Diana; Batalha, Vânia; Marques-Morgado, Inês; Coelho, Joana E; Pereira, Pedro; Gomes, Rui; Pinto, AndreiaSynaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described. In this study, we explore the synaptic function of A2AR in age-related conditions. We report, for the first time, a significant overexpression o...
Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locom...
Coelho, Joana E.; Alves, Pedro; Canas, Paula M.; Valadas, Jorge S.; Shmidt, Tatiana; Batalha, Vânia L.; Ferreira, Diana G.; Ribeiro, Joaquim A.Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertain, in particular in depression and anxiety. We have demonstrated an upsurge of A2AR associated ...
Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impa...
Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, ThomasParkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of the brain. In a...
Proteomics at the interface of psychology, gut physiology and dysfunction : an ...
Lopes, Luísa V.; Kussmann, MartinGut functions such as digestion and absorption are essential to life and the emerging insights into the gut–brain axis – that is,the cross talk between the enteric and CNS – point towards critical links between(eating)behavior,psychology,whole body and gut physiology,and digestive and overall health.While proteomics is ideally positioned to shed more light on these interactions,be it applied to the periphery (e...
Adenosine and related drugs in brain diseases : present and future in clinical ...
Lopes, Luísa V.; Sebastião, Ana M; Ribeiro, Joaquim A.Adenosine is a naturally occurring nucleoside present ubiquitously throughout the body as a metabolic intermediate. Besides its metabolic role within the cells, adenosine is released into the extracellular space either by neurons or astrocytes acting as a neuromodulator. Extracellular adenosine exerts its action by activating multiple G-protein coupled receptors (subtypes A1, A2A, A2B and A3) having a wide rang...
Modification of adenosine modulation of acetylcholine release in the hippocampu...
Rodrigues, Ricardo J.; Canas, Paula M.; Lopes, Luísa V.; Oliveira, Catarina R.; Cunha, Rodrigo A.Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory A2ARs. Since A2AR antagonists attenuate memory deficits in aged animals and memory deficits might involve a decreased cholinergic function, we investigated how aging affects the density and function of adenosine receptors in rat hippocampal cholinergic terminals. In young adult (2 months) rats, 64 and 36% of cholinergic...
Long-term Effect of Convulsive Behavior on the Density of Adenosine A1 and A2A ...
Rebola, Nelson; Porciúncula, Lisiane O.; Lopes, Luísa V.; Oliveira, Catarina R.; Soares-da-Silva, Patrício; Cunha, Rodrigo A.Purpose: Adenosine is a neuromodulator that has been proposed to act as an anticonvulsant mainly via inhibitory A1 receptors, but recent data show that genetic deletion of facilitatory A2A receptors might also attenuate convulsions. Since both A1 and A2A receptors are prone to down- and upregulation in different stressful situations, we investigated if convulsive behavior leads to a long-term change in A1 and A...