4 documents found, page 1 of 1
Molecular profiling, including TERT promoter mutations, of acral lentiginous me...
Vazquez, Vinícius Lima; Vicente, Anna L.; Carloni, Adriana C.; Berardinelli,Gustavo; Soares, Paula; Scapulatempo-Neto, Cristovam; Martinho, OlgaAcral lentiginous melanoma (ALM) is the less common subtype with singular characterization. TERT (human telomerase reverse transcriptase) promoter mutations have being described as recurrent in melanomas and infrequent in ALM, but their real incidence and clinical relevance is unclear. The objectives of this study were to describe the prevalence of TERT promoter mutations in ALM, and correlate with the molecula...
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147)...
Oliveira, Antônio Talvane Torres; Pinheiro, Céline; Filho, A. L.; Brito, Maria José; Martinho, Olga; Matos, Delcio; Carvalho, André LopesMonocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the i...
Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...
Oliveira, Antônio Talvane Torres; Reis, R. M.; Afonso, Julieta Alexandra Pereira; Martinho, Olga; Matos, Delcio; Carvalho, André LopesThis study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD ass...
Opportunistic screening for skin cancer using a mobile unit in Brazil
Mauad, Edmundo C.; Silva, Thiago Buosi; Latorre, Maria R. D. O.; Vieira, René A. C.; Haikel Junior, Raphael L.; Vazquez, Vinícius LimaBackground: Skin cancer is the most common malignancy in the white population worldwide. In Brazil, the National Cancer Institute (INCA) estimates that in 2010 there will be 119,780 and 5,930 new cases of nonmelanoma skin cancer and melanoma, respectively. The aim of this study was to evaluate the use of a mobile unit in the diagnosis and treatment of skin cancer in several poor regions of Brazil. Methods: The ...