Myasthenia gravis is an autoimmune disease that affects the neuromuscular junction, mainly through the action of pathogenic antibodies such as those directed against the nicotinic acetylcholine receptor or, more infrequently, against the muscle specific kinase. Other important components of the autoimmune process include the complement pathway and B and T cell populations. Diagnosis is based on the finding of f...
A miastenia gravis é uma doença autoimune da junção neuromuscular, cuja fisiopatologia consiste na produção de anticorpos patogénicos, mais frequentemente dirigidos contra o recetor nicotínico da acetilcolina e, mais raramente, contra a cinase específica do músculo. Outros elementos fisiopatológicos importantes incluem a cascata do complemento e as linhagens linfocitárias B e T. O diagnóstico assenta em fraquez...
Introduction: Sporadic Creutzfeldt-Jakob disease (sCJD) is the most frequent of human prion diseases, with an estimated incidence of 1 case per million / habitants per year. Clinical manifestations include multidomain cognitive impairment with pyramidal, extrapyramidal and/or cerebellar signs. It is a rapidly progressive and fatal disease. Our aim was to do a sociodemographic, clinical and progression evaluatio...
Multiple sclerosis (MS) and Charcot-Marie-Tooth disease (CMT) association has been reported, namely in CMTX and CMT1A. A 37-year-old woman with CMT type 2 (MFN2 mutation) developed subacute brainstem syndrome (left internuclear ophthalmoplegia, facial palsy and ataxia). Brain magnetic resonance imaging revealed infratentorial, periventricular and subcortical lesions, typical of MS (positive CSF oligoclonal band...
Este relatório de estágio resulta da necessidade de realizar um estágio curricular ou um projeto para poder concluir a unidade curricular, e assim terminar a licenciatura de Comunicação e Relações Públicas. no Politécnico da Guarda. Assim, tendo isso em conta, optei por realizar um estágio no Jornal O Interior, em que desempenhei múltiplas funções, desde a redação de notícias, breves, reportagens, participação ...
Introduction: Aspiration pneumonia is a severe complication of stroke, related to higher stroke severity, functional impairment and dysphagia grade, increasing mortality rate, length of hospitalization and health costs. The study aims to analyse the relationship between aspiration pneumonia, the clinical type and severity of ischemic stroke and its consequences and outcomes. Material and Methods: A retrospectiv...
Introduction: Leprosy is still one of the most frequent causes of peripheral neuropathy. Although regarded as eradicated in Portugal, is still documented in neuropathological study of patients with clinical peripheral neuropathy without proper diagnosis.Material and Methods: Review of the cases of Hansen disease neuropathy diagnosed in Neuropathology Unit of Centro Hospitalar do Porto between 1978 and 2013, ate...