4 documents found, page 1 of 1
Carcinogenic Ability of Schistosoma Haematobium Possibly through Oncogenic Muta...
Botelho, Mónica C.; Veiga, Isabel; Oliveira, Paula A.; Lopes, Carlos; Teixeira, Manuel; Costa, José M Correia da; Machado, José C.Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer, although why is not clear. Previously, we have used CD-1 mice to show that Schistosoma haematobium total antigen (Sh) has a carcinogenic ability. Sh intravesically instillation induced the development of several urothelial lesions, namely nodul...
TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset
Pinto, Carla; Veiga, Isabel; Pinheiro, Manuela; Peixoto, Ana; Pinto, Armando; Lopes, José M.; Reis, R. M.; Baptista, Manuela; Roque, LúciaThe Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant disease caused by TP53 germline mutations. This study aimed to characterize the TP53 mutational spectrum in patients suspected to have LFS in Portugal and to evaluate the influence of the MDM2-SNP309 and TP53-72Arg variants and of telomere length on age of tumor onset. Probands were primarily selected using the classical LFS criteria (two cases) or th...
Unidade remota de telegestão e controlo da qualidade da água
Veiga, Isabel; Claro, Pedro; Pacheco, Osvaldo; Martins, ErnestoToday, public health issues and environment concerns place tight quality control requirements on the water used for human consumption. These can only be met by monitoring networks, and a careful control of the captation, storage and distribution systems. This paper presents the architecture of a remote unit thatworks both as a water quality monitoring system and as aremote management terminal. The remote unit a...
E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations c...
Oliveira, Carla; Ferreira, Paulo; Nabais, Sérgio; Campos, Luísa; Ferreira, Ana; Cirnes, Luís; Alves, Catarina Castro; Veiga, Isabel; Fragoso, MariaApproximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds remain genetically unexplained and are probably caused by alterations in other genes. Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gas...