34 documents found, page 1 of 4
Obesity: hormonal regulation
Veiga, LuísaObesity is considered by WHO a public health problem, as the number of overweight people worldwide is now 1.9 billion, out of which approximately 600 million are obese. This condition is correlated with a high risk of cardiovascular disease, diabetes, hypertension, and cancer. This pathology arises as a consequence of an imbalance between energy intake and energy expended. This imbalance can result from psychol...
Magnetic resonance imaging in the study of the Locus Coeruleus and the relation...
Bulhões, Margarida; Ribeiro, Maria Margarida; Veiga, LuísaIntroduction: The progressive degeneration of LC neurons associated with a decrease in adrenergic receptors, targets of NA, leads to a decrease in brain function, causing a low hemodynamic response and neuronal activity. Noradrenergic dysfunction can also interrupt the ability to monitor external stimuli and alter the cognitive process of attention, as in AD and PD. Objectives: The investigation sought to unite...
The use of next-generation sequencing in the study of monogenic obesity
Serrasqueiro, Bernardo; Veiga, Luísa; Silva-Nunes, José; Brito, MiguelTechnological innovation opens the possibility for scientific discovery, especially in biology and medicine, which allows the development of different perspectives that can bring a new understanding regarding different pathologies. Technologies such as the Next-Generation Sequencing (NGS) allow us not only to decode the human genome but also to describe and identify gene polymorphisms that lead to the developme...
Oxytocin and mental health in college students
Veríssimo, Carolina; Santos, Margarida Custódio dos; Brito, Miguel; Veiga, LuísaMental health is the result of a combination of many factors and has a great influence on multiple aspects of the life of young adults. Some studies have found associations between oxytocin levels and quality of social relations and mental health disorders. The concern with students' mental health is increasing because most mental disorders peak during or slightly before college age. Of the mental disorders in ...
A utilização da ‘Next-Generation Sequencing’ no estudo da obesidade monogénica
Serrasqueiro, Bernardo; Veiga, Luísa; Silva-Nunes, José; Brito, MiguelObjetivo do estudo: Prevalência de mutações associadas à obesidade monogénica numa amostra de 36 pacientes obesos portugueses, utilizando tecnologia de sequenciação NGS.
Influência da obesidade, dieta e exercício físico no comprimento dos telómeros
Coutinho, Filipa; Pinto, Jéssica; Brito, Miguel; Veiga, LuísaOs biomarcadores do envelhecimento são cada vez mais utilizados para identificar indivíduos que apresentem maior risco de desenvolver doenças relacionadas com o envelhecimento. Assim, os telómeros que são regiões repetitivas de nucleótidos localizados nas terminações dos cromossomas humanos, são reconhecidos como bons biomarcadores do envelhecimento. O comprimento dos Telómeros, é afetado por fatores de estilo ...
Monogenic obesity in Portugal: the use of next generation sequencing (prelimina...
Brito, Miguel; Serrasqueiro, Bernardo; Veiga, Luísa; Silva-Nunes, JoséObesity arises from a complex interaction between genetic variance, environment, and lifestyle changes, and has become a major public health problem as a result of its increasing prevalence in most developed countries. Several genes have been implicated in obesity, namely ADRB1, ADRB2, ADRB3, BDNF, FTO; IGF2, IGF2R, LEP, LEPR, LRP2, MC1R; MC2R; MC3R; MC4R; NEGR1, NPY, NPY2R; NPY1R; NTRK2, PCSK1, POMC; SH2B1; SI...
In the Child’s Best Interest: The Contribution of Child and Adolescent Psychiatry
Leite, Víitor Ferreira; Araújo, Carla; Cartaxo, Teresa; Veiga, Luísa; Loureiro, Mário JorgeIntroduction: Child and Adolescent Forensic Psychiatry involves a multidisciplinary assessment at the courts’ requested to assist them in the process of justice delivery.Material and Methods: Retrospective study which included 233 forensic requests to two child and adolescent psychiatrists from Coimbra’s HP-CHUC Child and Adolescent Psychiatry Department between 1998 and 2012.Results: Biographic, psychopatholog...
Unacylated ghrelin does not seem to influence glucose homeostasis in obese women
Silva-Nunes, José; Brito, Miguel; Silva, Carina; Oliveira, Ana Cebola; Veiga, LuísaBackground and Aim: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a non-functional peptide, soon after UAG has been associated with a negative action on energy balance, suppression of hepatic glucose production and a decrease in circulating levels of insulin. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism p...
Occupational exposure to aflatoxin B1: the case of a poultry slaughterhouse
Viegas, Susana; Veiga, Luísa; Almeida, Ana; Santos, Mateus dos; Carolino, Elisabete; Viegas, CarlaAflatoxin B1 (AFB1) is a secondary metabolite produced by the fungi Aspergillus flavus and is the most potent hepatocarcinogen known in mammals and has been classified by the International Agency of Research on Cancer as Group 1 carcinogen. Although dietary exposure to AFB1 has been extensively documented, there are still few studies dedicated to the occupational exposure topic. In view of the recent findings r...