14 documents found, page 1 of 2
A implementação de um rastreio neonatal de doença das células falciformes em An...
Brito, Miguel; Ginete, Catarina; Inusa, Baba; Mendes, Manuela; Vasconcelos, Jocelyne Neto; Veiga, LuisaIntrodução: A doença das células falciformes (DCF) é uma doença hereditária severa, com uma incidência especialmente elevada na África subsariana, sendo responsável por 50% da mortalidade em crianças com menos de 5 anos. A prevalência desta doença genética em Angola ronda os 2%, sendo a doença genética mais frequentes no mundo. A identificação da doença à nascença permite o seguimento das crianças em consultas ...
Telomeres are shorter in Portuguese obese adults
Duarte, Catarina; Braz, Maria Teresa; Marques-Ramos, Ana; Silva-Nunes, José; Veiga, Luisa; Brito, MiguelObesity is a clinical condition characterized by an abnormal accumulation of adipose tissue with an increased risk of developing illnesses such as type 2 diabetes, cardiovascular disease, and cancer. In obesity, the secretion of proinflammatory adipokines contributes to oxidative stress that can lead to a decline in the length of telomeres. Telomeres are structures of repetitive sequences delimiting the chromos...
Differential expression of adhesion molecules in sickle cell anemia and gut mic...
Delgadinho, Mariana; Veiga, Luisa; Ginete, Catarina; Santos, Brígida; Miranda, Armandina; Vasconcelos, Jocelyne Neto de; Brito, MiguelSickle cell anemia (SCA) causes a long-standing vascular inflammation state, leading to endothelial dysfunction and chronic overexpression of several adhesion molecules, which contributes to acute and constant vaso-occlusive (VOC) episodes. It has been demonstrated that hydroxyurea (HU) can reduce VOC events, organ damage, blood transfusions, and even the adhesion properties to endothelial cells of SCA subjects...
The interplay between HPV, other sexually transmissible infections and genital ...
Gonçalves-Nobre, J. Guilherme; Matos, Andreia; Carreira, Mariana; Santos, Ana Carolina; Veiga, Luisa; Ginete, Catarina; Brito, Miguel; Pires, MarinaBackground: The importance of Cervicovaginal Microbiota in protecting against infections (such as HPV) is already well established, namely through Lactobacillus spp., as well as the mechanism through which HPV leads to Cervical Neoplasia. However, it is not possible to classify HPV as a complete carcinogen. Thus, the importance of exploring Cervicovaginal dysbiosis to decipher this interaction with HPV takes on...
The nuclear levels of thioredoxin reductase 1, gamma-H2AX, and yap are modulate...
Marques, Rita; Ginete, Catarina; Veiga, Luisa; Brito, Miguel; Soares, Helena; Carmona, Bruno; Paiva, Mariana; Nolasco, Sofia; Marinho, Susana H.Diabetes is a condition characterized by impaired regulation of blood glucose levels, leading to various complications such as hypertension, cardiovascular disease, and retinopathy. Diabetic retinopathy (DR), caused by a disrupted retinal blood barrier, is associated with oxidative stress resulting from dysregulated glucose levels in the retina. The primary cilium, an organelle involved in energy balance and gl...
Os cílios primários regulam os níveis de tiorredoxina redutase 1 e de yH2AX em ...
Marques, Rira; Paiva, Mariana; Ginete, Catarina; Nolasco, Sofia; Marinho, Susana H.; Veiga, Luisa; Brito, Miguel; Soares, Helena; Carmona, BrunoA diabetes caracteriza-se por uma anormal capacidade de controlar o nível de glucose na corrente sanguínea, podendo levar a outras complicações, tais como hipertensão, doenças cardiovasculares, e retinopatia. A desregulação dos níveis de glucose na retina tem demonstrado aumentar os níveis de peróxido de hidrogénio, conduzindo a uma rutura na barreira sanguínea da retina, uma das causas de retinopatia diabética...
Ressonância magnética no estudo do Locus coeruleus e a relação com o processo c...
Bulhões, Margarida; Ribeiro, Maria Margarida; Veiga, LuisaIntrodução: A degeneração progressiva dos neurónios do Locus Coeruleus associada à diminuição de recetores adrenérgicos, alvos da Noradrenalina, conduz a uma diminuição da função cerebral, provocando uma baixa resposta hemodinâmica e atividade neuronal. A disfunção noradrenérgica pode, ainda, interromper a capacidade de monitorizar estímulos externos e alterar o processo cognitivo da atenção, como acontece na D...
Depressive symptomatology, temperament and oxytocin serum levels in a sample of...
Veiga, Luisa; Carolino, Elisabete; Santos, I.; Veríssimo, C.; Almeida, Ana; Grilo, Ana Monteiro; Brito, Miguel; Santos, Margarida Custódio dosBackground: Depressive symptomatology is prevalent among female university students with adverse effects on their quality of life and academic performance. Previous research suggested associations between depressive symptomatology and oxytocin levels and between depressive symptomatology and Temperament Traits. Despite this evidence, to the best of our knowledge, no research has studied the effects of both oxyt...
Identification of genetic variants in 65 obesity related genes in a cohort of P...
Ginete, Catarina; Serrasqueiro, Bernardo; Silva-Nunes, José; Veiga, Luisa; Brito, MiguelObesity is a major public health problem, which has a strong genetic component that interplays with environmental factors. Several genes are known to be implicated in the regulation of body weight. The identification of alleles that can be associated with obesity is a key element to control this pandemic. On the basis of a Portuguese population, 65 obesity-related genes are sequenced using Next-Generation Seque...
Glucose homeostasis in obese women is not associated to unacylated ghrelin plas...
Veiga, Luisa; Brito, Miguel; Silva, Carina; Silva-Nunes, JoséIntroduction: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a nonfunctional peptide, soon after, UAG has been associated with an insulin-sensitizing action and to negative action on energy balance. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual infl...