4 documents found, page 1 of 1
Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation
Rodrigues, Fernando José dos Santos; Cunha, Cristina; Aversa, Franco; Lacerda, João F.; Busca, Alessandro; Kunzai, Oliver; Grube, MatthiasBACKGROUND: The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity. The contribution of single-nucleotide polymorphisms (SNPs) in PTX3 to the development of invasive aspergillosis is unknown. METHODS: We screened an initial cohort of 268 patients undergoing hematopoietic stem-cell transplantation (HSCT) and their donors for PTX3 SNPs modifying th...
TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell resp...
Carvalho, Agostinho; De Luca, Antonella; Bozza, Silvia; Cunha, Cristina; D’Angelo, Carmen; Moretti, Silvia; Perruccio, Katia; Iannitti, Rossana G.Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections and diseases. CD8+ T cells are present in the human and murine T-cell repertoire to the fungus. However, CD8+ T-cell function in infection and the molecular mechanisms that control their priming and differentiation into effector and memory cells in vivo remain elusive. In the present study, we report that both CD4+ and CD8+...
Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor fo...
Cunha, Cristina; Giovannini, Gloria; Pierini, Antonio; Bell, Alain S.; Sorci, Guglielmo; Riuzzi, Francesca; Donato, RosarioInvasive aspergillosis (IA) is a major threat to the successful outcome of hematopoietic stem cell transplantation (HSCT), although individual risk varies considerably. Recent evidence has established a pivotal role for a danger sensing mechanism implicating the S100B/receptor for advanced glycation end products (RAGE) axis in antifungal immunity. The association of selected genetic variants in the S100B/RAGE a...
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergil...
Cunha, Cristina; Ianni, Mauro Di; Bozza, Silvia; Giovannini, Gloria; Zagarella, Silvia; Zelante, Teresa; Angelo, Carmen de; Pierini, AntonioThe C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study, the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading to diminished Dectin-1 receptor activity was studied in relation to invasive aspergillosis susceptibility and severity in patients receiving hematopoietic stem cell transplantation. We found that the presence of the DECTIN1 Y238X pol...