16 documents found, page 1 of 2

Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis an...

Sepsis is a life-threatening organ dysfunction syndrome that results from a dysregulated host response to infection. Our evolving understanding of sepsis pathophysiology now incorporates insights from molecular advances, particularly in the felds of immunity and, more recently, metabolism. The concept that sepsis induces metabolic perturbations is not new. In fact, hyperlactatemia, metabolic acidosis, hypochole...

Predicting the burden for surgical aortic valve replacement in a tertiary centr...

Background/Objectives: The incidence of aortic stenosis (AS) is predicted to rise with the aging population, emerging as a growing public health challenge in developed countries, leading to an increased demand for intervention. Our aim is to predict the evolution of proposed cases for SAVR in the geographic referral area of our tertiary hospital until 2041. Methods: We used data from the Portuguese Census for 2...

Growth differentiation factor 15 as a biomarker for risk stratification in the ...

Growth Differentiation Factor 15 (GDF15) is an emerging biomarker that significantly increases during acute stress responses, such as infections, and is moderately elevated in chronic and inflammation-driven conditions. While evidence suggests that high levels of GDF15 in cardiac surgery are associated with worse outcomes, its utility as an evaluator of early postoperative complications remains unclear. This st...

Extracorporeal life support in cardiogenic shock: exploring before liberalizing

Cardiogenic shock (CS) is the leading cause of death after acute myocardial infarction (AMI), affecting up to 10% of the patients. Despite all the recent advances, CS is invariably associated with mortality rates around 40-50%. Interestingly, some reports even describe a recent increase in the probability of developing CS after AMI and in the mortality rates, probably due to ageing of population and increased r...

Venoarterial extracorporeal membrane oxygenation is routinely used in the inten...

Recently, Thiele H et al. published an article summarizing new evidence on the use of routine venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock. VA-ECMO plays an unquestionable role in the management of critical patients with cardiac failure. Its use has been steadily increasing despite constant rates of mortality and related complications. Recent trials, such as VA-ECMO-CS and ELC...

Post-cardiotomy bronchopericardial fistula

We report a case of a 65 years-old woman submitted to an aortic and mitral valve replacement with mechanical prosthesis (St Jude 19mm and St Jude 21mm, respectively), who developed a postoperative cardiogenic shock, with necessity of mechanical support with extracorporeal membrane oxygenation and intra-aortic pump balloon.

Surgical aortic valve replacement in octogenarians: single-center perioperative...

Introduction and objectives: Aortic stenosis is the most common valvular heart disease. The number of octogenarians proposed for intervention is growing due to increased lifespan. In this manuscript we aim to evaluate perioperative outcome and long-term survival after surgical aortic valve replacement (SAVR) in octogenarians, comparing patients with low surgical risk (EuroscoreII <4%) with intermediate-high ris...

Extracorporeal life support in cardiogenic shock: exploring before liberalizing

Post-cardiotomy Bronchopericardial Fistula

Postoperative organ dysfunction signatures of cardic surgery

A cirurgia cardíaca sofreu uma transformação e crescimento impressionantes nas últimas décadas, permitindo que o foco da investigação seja atualmente colocado na perturbação da homeostasia peri-operatória. A cirurgia cardíaca induz perturbações homeostáticas importantes, principalmente como consequência da síndrome de resposta inflamatória sistémica (SIRS), sendo responsável pela ocorrência de disfunção de órgã...