37 documents found, page 1 of 4
Evaluation of the photothermal performance of the Prussian blue/hydroxyapatite ...
Costa, Achilley Nahid Barros; Serra, Josilene Lima; da Luz Rodrigues, Israel; Mendonça, Leonardo Tadeu Boaes; Pereira, GoretiIn this study, Prussian Blue (PB) and hydroxyapatite (HAp) composites were developed and synthesized in situ within an alginate gel, resulting in materials with excellent photothermal conversion efficiency. Structural information and morphology of the composites were obtained by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), UV–vis absorption spectroscopy, and Scanning Electron M...
Albumin/Hyaluronic acid nanoparticle-laden contact lenses for the ocular delive...
Senra, Sara F. M.; Veloso, Sérgio Rafael Silva; Lira, Madalena; Castanheira, Elisabete M. S.Nanoparticle-laden contact lenses are a formidable strategy for ocular drug delivery. However, incorporating nanoparticles to achieve sustained drug release without affecting the contact lenses' properties remains a challenging task. In this work, daily and monthly replacement silicone-hydrogel contact lenses laden with bovine serum albumin/hyaluronic acid (BSA/HA) nanoparticles are presented. These nanoparticl...
Chitosan/alginate polyelectrolyte magnetic gel nanoarchitectonics with tunable ...
Veloso, Sérgio Rafael Silva; Vázquez-González, Margarita; Ribeiro, Mariana O.; Hilliou, L.; Amorim, Carlos O.; Amaral, Vítor S.Chitosan-based hydrogels hold promise as drug delivery systems for cancer therapy, but the poor mechanical properties often limit the biological application, requiring chemical cross-linking to improve sustained drug release. Besides, the addition of stimulus-responsiveness to chitosan requires chemical modifications that can further affect the gel properties. To overcome these challenges, in this work, a novel...
Development of multifunctional supramolecular magnetogels for multimodal cancer...
Veloso, Sérgio Rafael SilvaApós várias décadas, o cancro continua a ser um desafio de saúde, social e económico, em que as dificuldades inerentes à quimioterapia têm sido ultrapassadas por via da nanomedicina. Particularmente, os hidrogéis magnéticos, que consistem em hidrogéis com nanopartículas magnéticas, têm contribuído para novas estratégias de contraste em técnicas de imagiologia e de combinação com a terapia, numa tentativa dinâmi...
New strategies for multimodal cancer therapy based on plasmonic lipogels
Veloso, Sérgio Rafael Silva; Sá, Filipa Costa e; Comís-Tuche, María; Spuch, Carlos; Castanheira, Elisabete M. S.Enhancing the therapeutic efficacy of chemotherapeutic agents through sequential drug delivery holds immense promise, yet current strategies are mainly dependent on the tumour microenvironment. Natural polymer-based hydrogels present suitable properties for these applications, owing to their inherent biocompatibility [1]. Herein, we present a novel strategy aimed at improving the tunability and real-time contro...
Sequential release of drugs from dual-delivery plasmonic nanogels containing li...
Costa-e-Sá, Filipa; Comís-Tuche, María; Spuch, Carlos; Castanheira, Elisabete M. S.; Veloso, Sérgio Rafael SilvaNanosystems that enable the sequential delivery of various drugs with different targets are desired for improved cancer therapy. However, current strategies are mainly dependent on the tumour microenvironment, such as low pH or enzyme-triggered release. In this work, a nanosystem design strategy for near infrared (NIR) light-triggered sequential delivery based on lipid-gated mesoporous silica-coated gold nanoro...
Citrate-coated manganese and calcium ferrite nanoparticles as potential magneti...
Andrade, Raquel G. D.; Ferreira, Débora Carina Gonçalves Abreu; Veloso, Sérgio Rafael Silva; Santos-Pereira, Cátia; Castanheira, Elisabete M. S.In this work, manganese/calcium ferrite NPs coated with citrate, were synthesized by the sol-gel method, followed by calcination, and then characterized regarding their crystalline structure (by X-ray diffraction, XRD), size and shape (by Transmission Electron Microscopy, TEM), hydrodynamic size and zeta potential (by Dynamic Light Scattering, DLS), and heating efficiency (measuring the Specific Absorption Rate...
Magnetic lipid-based nanoparticles: recent advances in therapeutic applications
Andrade, Raquel G. D.; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Rodrigues, L. R.In the realm of modern medicine, the pursuit of innovative solutions to enhance therapeutic applications has led to the exploration of cutting-edge technologies. The convergence of nanotechnology and medicine has marked a new era, where the scale of interventions has shifted to the molecular level. Nanoparticles with their ability to navigate through biological barriers, coupled with the potential for targeted ...
Synthesis of cobalt-doped manganese ferrites through eco-friendly methods for t...
Veloso, Sérgio Rafael Silva; Nereu, Sara F.; Amorim, Carlos O.; Amaral, Vítor S.; Correa-Duarte, M.; Castanheira, Elisabete M. S.In this work, multi- and single-core citrate-stabilized cobalt and/or manganese-doped ferrite (CoxMn1-xFe2O4, 0 ≤ x ≤ 1) nanoparticles were synthesized through eco-friendly methods: oxidative precipitation and oxidative hydrothermal synthesis.
Influence of the lens material in daily CLs incorporating drug-loaded Chitosan/...
Vale, Sofia; Veloso, Sérgio Rafael Silva; Lira, Madalena; Castanheira, Elisabete M. S.Purpose: To investigate the behavior of different contact lens materials with incorporated Chitosan/Hyaluronic Acid (Ch/HA) nanoparticles loaded with the anticancer drug methotrexate (MTX). Methods: MTX-loaded nanoparticles were characterized with respect to their size and zeta potential (by Dynamic Light Scattering), stability, drug encapsulation efficiency, drug loading capacity and release profile (using UV/...