- DOI: http://doi.org/10.11606/issn.2316-9044.v20i3p261-275; Submitted by Maria Fernanda Leite (leitem@stj.jus.br) on 2021-02-16T21:36:16Z No. of bitstreams: 2 direito_saude_mental_figueiredo.pdf: 202611 bytes, checksum: 5cf040ecef173fcce8b40bc6806470c9 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5); Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on...
In this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian and Berenice-78, was compared to isolates obtained from dogs infected with these strains for several years. In order to evaluate the susceptibility to benznidazole two groups of mice were infected with one of five distinct populations isolated from dogs as well as the two parental strains of T. cruzi. The first...
Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, obser...
The present study aims at establishing whether the diversity in pathogenesis within a genetically diverse host population infected with a single polyclonal strain of Trypanosoma cruzi is due to selection of specific subpopulations within the strain. For this purpose we infected Swiss mice, a genetically diverse population, with the polyclonal strain of Trypanosoma cruzi Berenice-78 and characterized via LSSP-PC...
Este trabalho foi composto por um estudo transversal, feito em Ouro Preto, Minas Gerais,Brasil, para avaliar os fatores associados à qualidade de vida em mulheres no climatério.Foram usados o questionário de qualidade de vida SF-36 e uma entrevista sobre dados soci-oeconômicos, demográficos, uso de medicamentos e hábitos de vida. A média de idadedas 113 participantes foi de 53,3 ± 4,4 anos. Dessas, 49,6% conviv...
We developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid 100% mortality of untreated animals at acute phase. Treatment allowed animals to be kept infected and alive in ord...
Background: Trypanosoma cruzi is classified into six discrete taxonomic units (DTUs). For this classification, different biological markers and classification criteria have been used. The objective was to identify the genetic profile of T. cruzi samples isolated from patients of two municipalities of Jequitinhonha Valley, MG, Brazil. Methods: Molecular characterization was performed using two different criteria...
Chemokines and chemokine receptors interaction have presented important role in leukocyte migration to specific immune reaction sites. Recently, it has been reported that chemokine receptors CXC (CXCR3) and CC (CCR5) were preferentially expressed on Th1 cells while CCR3 and CCR4 were preferentially expressed on Th2 cells. This study evaluated the mRNA expression of type 1 and type 2 chemokine and chemokine rece...
Zoonotic visceral leishmaniasis in Brazil is caused by Leishmania infantum parasites andis transmitted by sand flies of the Phlebotominae family. Dogs are the main urban reser-voirs and represent the major source of contagion for the vectors. Studies have shown thatmost infected dogs are polymerase chain reaction-positive months before seroconversion.Herein, we describe a cohort study designed to identify the i...