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Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in m...

Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Chaves Filho, Adriano José Maia; Rios, Emiliano Ricardo Vasconcelos

This study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of o...

Date: 2016   |   Origin: Oasisbr

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