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Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opp...

Fesel, C.; Barreto, M.; Ferreira, R.C.; Costa, N.; Venda, L.L.; Pereira, C.; Carvalho, C.; Morães-Fontes, M.F.; Ferreira, C.M.; Vasconcelos, C.

In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity, usually without ever acquiring the disease. We studied relations of IgG autoantibody profiles and peripheral blood activated regulatory T-cells (aTregs), represented...

Date: 2012   |   Origin: Repositório Científico do Instituto Nacional de Saúde
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