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The effects of the novel A53E alpha-synuclein mutation on its oligomerization a...

Lázaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina S; Tenreiro, Sandra; Ventura, Salvador; Outeiro, Tiago F

α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the accumulation of aSyn in Lewy Bodies and Lewy neurites in disorders such as PD, dementia with Lewy bodies, or multi...


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Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Arozena, Abraham Acevedo; Adachi, Hiroaki


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