9 documents found, page 1 of 1

Relationship of Demoralization With Anxiety, Depression, and Quality of Life: a...

Background: Demoralization syndrome is a significant condition that has not been greatly studied in Southern European countries. Aims: To extend the knowledge of demoralization in Southern Europe by examining its prevalence according to different methods of assessment, its relationship with anxiety and depression, and its impact on quality of life (QoL) among cancer patients. Methods: A convenience sample of 19...

PROS1 novel splice-site variant decreases protein S expression in patients from...

Our results prove that c.1871-14T>G is causative of type I PS deficiency, highlighting the importance of performing mRNA-based studies in order to evaluate variants pathogenicity. We evidence the increased risk of venous thromboembolism associated with this cryptic splice-site variant if present in patients with PS deficiency.

First report of acute autochthonous hepatitis E in Portugal

Hepatitis E infection is usually a self-limiting disease. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described; their number seems to be increasing in European countries. We report the first human case of autochthonous acute hepatitis E confirmed in Portugal. Patients with acute non-A-C hepatitis should be tested for HEV in Portugal and hepatitis E infectio...

Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed ...

We describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery phase. This occu...

Do Spirituality and Faith Make a Difference? Report from the Southern European ...

OBJECTIVE: In the last decade, some attention has been given to spirituality and faith and their role in cancer patients' coping. Few data are available about spirituality among cancer patients in Southern European countries, which have a big tradition of spirituality, namely, the Catholic religion. As part of a more general investigation (Southern European Psycho-Oncology Study--SEPOS), the aim of this study w...

The Spectrum of Mutations and Molecular Pathogenesis of Hemophilia A in 181 Por...

Disease-causing alterations within the F8 gene were identified in 177 hemophilia A families of Portuguese origin. The spectrum of non-inversion F8 mutations in 101 families included 67 different alterations, namely: 36 missense, 8 nonsense and 4 splice site mutations, as well as 19 insertions/deletions. Thirty-four of these mutations are novel. Molecular modeling allowed prediction of the conformational changes...

Physician-Patient Communication Among Southern European Cancer Physicians: the ...

Physician-patient communication is a critical factor for comprehensive care in oncology. Although a number of studies have been carried out in Northern Europe and the US on this subject, no data are available in Southern European countries. As a part of a multicenter Southern European Psycho-Oncology study (SEPOS), the present investigation was conducted to examine communication skills and related variables (i....

Abordagem Psicológica da Obesidade Mórbida. Caracterização e Apresentação do Pr...

A obesidade mórbida (OM) é uma versão patológica de obesidade considerada um grave problema de saúde para os indivíduos que dela sofrem. O seu tratamento deve ser baseado numa abordagem biopsicossocial do indivíduo e do seu processo de doença que assegure o êxito do tratamento, a curto e longo prazo. A abordagem psicológica de cariz cognitivocomportamental estrutura-se ao longo das 3 principais fases do process...

Application of QSAR to the Modelling of Tuberculostatics-Preliminary Studies