This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5 coding region, which is followed by Sanger population sequencing. NS5A RASs were present in 28.4% (23/81) of all G...
ABSTRACT: Between 1997 and 1999, a Sustainable Production Programme was developed in the Portuguese Setubal region. In this paper its final results are presented. The programme included cleaner production (CP) demonstration projects developed in 10 companies located in the region and the involvement of local stakeholders, aiming at stimulating the diffusion and application of sustainable development principles ...
ABSTRACT: In this paper the PROSSET Programme is described briefly and the preliminary results are presented. The Programme includes cleaner production (CP) demonstration projects developed in 10 companies located in the Setúbal Region and the testing of methodologies to promote the sustainability of the Programme. Both the involvement of local agents and the training and/or awareness of workers and locals were...
ABSTRACT: In this paper the PROSSET Programme is described briefly and the preliminary results are presented. The Programme includes cleaner production (CP) demonstration projects developed in 10 companies located in the Setúbal Region and the testing of methodologies to promote the sustainability of the Programme. Both the involvement of local agents and the training and/or awareness of workers and locals were...