Enquadramento: O Daratumumab (anti-CD38) é um anticorpo monoclonal IgG amplamente utilizado no tratamento de doenças hemato-oncológicas como no caso do Mieloma Múltiplo (MM). O Daratumumab liga-se ao CD38 expresso pelos eritrócitos causando uma panaglutinação nos testes pré-transfusionais, nomeadamente Pesquisa de Anticorpos Irregulares (PAI) e Provas de Compatibilidade (PC) [1]. O reagente Ditiotreitol (DTT) t...
Introduction: Many survivors of polio develop complications after a period of clinical stability. This case report demonstrates the need for the family physician to become familiar with the multiple facets of the late effects of polio and to recognize them as a disease entity. Description of the case: A 69 year-old woman had polio with sequelae. Her life story showed how the struggle to overcome deficiency was ...
Introduction: Adaptation to a diagnosis of cancer has aspects common to all patients, regardless of the path each individual takes. In this case, we show how the challenges faced by the patient were shaped by their specific circumstances. Description of the case: A 53-year-old businesswoman from an African country was diagnosed with breast cancer during a visit to Portugal. The patient perceived the disease and...
Introduction: The co-existence of depression and chronic disease is frequent. This association leads to a worse evolution, of both the psychiatric framework and the chronic disease. However, the depression diagnosis is not always evident and even when it is identified correctly it is often under-treated, either for reasons imputable to the doctor or due to the patients poor adhesion to the therapeutics. Descri...
The identification of the characteristics necessary for the performance, quality, functions guiding postgraduate medical training is a necessity of proper training and the institutions responsible for their professional qualification. It thus define a Competency Profile of guiding doctors in training which meets the needs of a training process (specialization) that arises primarily in the context of real work. ...