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In vitro and skin lesion cytokine profile in Brazilian patients with borderline...
Venturini, James [UNESP]; Soares, Cléverson Teixeira; Belone, Andréa de Faria Fernandes; Barreto, Jaison Antonio; Ura, SomeiMade available in DSpace on 2022-04-28T18:56:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-03-01; Objective: We investigated the in vitro and skin lesions production of cytokines in non-treated borderline tuberculoid (BT) and borderline lepromatous (BL) patients. Patients and Methods: Seven untreated, non-reactional BT patients and 12 untreated, non-reactional BL patients were studied. Levels of the...
IFN-γ Mediated Signaling Improves Fungal Clearance in Experimental Pulmonary Mu...
dos Santos, Amanda Ribeiro [UNESP]; Fraga-Silva, Thais Fernanda; de Fátima Almeida-Donanzam, Débora [UNESP]; dos Santos, Rodolfo Ferreira [UNESP]Made available in DSpace on 2022-04-29T08:46:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); We established three immunocompetent murine models of pulmonary mucormycosis to determine the involvement of the adaptive immune response in host resistance in pulmonary mucormycosis, a rapidly fatal disease caused mainly by Rhizopus spp. Im...
A New Curcuminoids-Coumarin Derivative: Mechanochemical Synthesis, Characteriza...
de Moura, Aniele [UNESP]; Gaglieri, Caroline [UNESP]; Alarcon, Rafael Turra [UNESP]; Ferreira, Laura Teófilo [UNESP]; Vecchi, Rafael [UNESP]Made available in DSpace on 2022-04-29T08:46:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-08; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Over the years, several drugs have been developed deriving from plants to investigate possible therapeutic roles. Among them, curcuminoids and coumarins, which, display a wide range of biological activity against several strains. There...
Rare-earth complexes with anti-inflammatory drug sulindac: Synthesis, character...
Barrach Guerra, Renan [UNESP]; Alves Gálico, Diogo; Fernanda de Campos Fraga-Silva, Thais [UNESP]; Aguiar, Julia [UNESP]; Venturini, James [UNESP]Made available in DSpace on 2022-05-01T07:58:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; New rare-earth complexes with the general formula [LnIII(sul)3]∙nH2O, where sul− is the anti-inflammatory drug sulindac and Ln3+ = Ce3+, Pr3+, Gd3+, Tb3+, and Ho3+, were synthesized, characterized, and had their cytotoxic activity and anti-inflammatory profile assessed. Characterization employing elemen...
Proteomic analysis of serum samples of paracoccidioidomycosis patients with sev...
Dos Santos, Amanda Ribeiro [UNESP]; Dionizio, Aline; Da Silva Fernandes, Mileni; Rabelo Buzalaf, Marılia Afonso; Pereira, Beatriz [UNESP]Made available in DSpace on 2022-05-01T09:00:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-01; Background Pulmonary sequelae (PS) in patients with chronic paracoccidioidomycosis (PCM) typically include pulmonary fibrosis and emphysema. Knowledge of the molecular pathways involved in PS of PCM is required for treatment and biomarker identification. Methodology/Principal findings This non-concurren...
Exoantigens of Paracoccidioides spp. Promote Proliferation and Modulation of Hu...
Almeida Donanzam, Débora de Fátima [UNESP]; Donato, Tatiani Ayako Goto [UNESP]; Reis, Karoline Haghata dos [UNESP]; Silva, Adriely Primo da [UNESP]Made available in DSpace on 2021-06-25T10:44:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-30; Paracoccidioidomycosis (PCM) is a systemic granulomatous fungal infection caused by thermally dimorphic fungi of the genus Paracoccidioides. Endemic in Latin America, PCM presents with high incidence in Brazil, Colombia, and Venezuela, especially among rural workers. The main clinical types are acute/su...
Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice
Dos Santos, Amanda R. [UNESP]; Fraga-Silva, Thais F. [UNESP]; Almeida, Débora de F [UNESP]; Dos Santos, Rodolfo F. [UNESP]; Finato, Angela C. [UNESP]Made available in DSpace on 2020-12-12T01:34:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immun...
Enhanced expression of NLRP3 inflammasome components by monocytes of patients w...
Amorim, Barbara Casella [UNESP]; Pereira-Latini, Ana Carla; Golim, Márjorie de Assis [UNESP]; Ruiz Júnior, Raul Lopes [UNESP]Made available in DSpace on 2020-12-12T02:31:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Paracoccidioidomycosis (PCM) is a systemic mycosis caused by thermally dimorphic fungi of the genus Paracoccidioides that affects predominantly 30-60-year-old male r...
Lanthanum(III) and neodymium(III) complexes with anti-inflammatory drug sulinda...
Guerra, Renan B. [UNESP]; de Campos Fraga-Silva, Thais Fernanda [UNESP]; Aguiar, Julia [UNESP]; Oshiro, Paula B. [UNESP]; Holanda, Bruno B.C. [UNESP]Made available in DSpace on 2020-12-12T02:32:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); New lanthanum(III) and neodymium(III) complexes with the anti-inflammatory drug sulindac (Sul) were synthesized and characterized, and their biological activity was evalua...
Gliotoxin aggravates experimental autoimmune encephalomyelitis by triggering ne...
Fraga-Silva, Thais Fernanda de Campos [UNESP]; Mimura, Luiza Ayumi Nishiyama [UNESP]; Leite, Laysla de Campos Toledo [UNESP]Made available in DSpace on 2019-10-06T16:42:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Gliotoxin (GTX) is the major and the most potent mycotoxin that is secreted by Aspergillus fumigatus, which is capable of injuring and killing microglial cells, astrocytes, and oligodendrocytes. During the last years, studies with patients a...