This work was supported by Funda??o Cearense de Apoio ao Desenvolvimento Cient?fico e Tecnol?gico - FUNCAP (grant N? 178638234); and the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - Brasil (CAPES) - Finance Code 001.; Universidade Federal do Cear?. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brazil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. I...
In Fortaleza, the capital of Ceara State, Brazil, the detection rate of tuberculosis (TB) in 2018 was 65.5/100,000 inhabitants with a cure rate of 59.1%, which is higher than the country average. This study investigated the risk factors associated with drug-resistant tuberculosis (DR-TB) and identified the drug-resistance phenotype and resistance-conferring mutations. The geographic distribution of DR-TB in For...
The essential oil (EO) extracted from the bark of Cinnamomum zeylanicum (Czey; also known as cinnamon), mostly derives its properties from its major compound trans-cinnamaldehyde (TCin). The present study evaluated the antimycobacterial activity of the essential oil from Czey (CzeyEO) and TCin against sensitive and resistant clinical isolates of Mycobacterium tuberculosis, as well as the combinatorial effects o...
The tuberculosis (TB) disease is highly infectious, caused by the bacillus Mycobacterium tuberculosis, and it is estimated that a quarter of the world's population is infected. Brazil is among the 20 countries responsible for 84% of TB cases. Resistant multidrug TB (MDR) is defined as resistance to isoniazid (I) and rifampicin (R) and is a serious problem for TB control. According to the World Health Organizati...
O aumento contínuo dos casos de resistência do Mycobacterium tuberculosis se tornou um grande obstáculo para o controle efetivo da tuberculose (TB) no mundo. Acredita-se que as plantas medicinais, através dos óleos essenciais (OEs), sejam as melhores alternativas para descoberta de novos fármacos, como o OE extraído da casca de Cinnamomum zeylanicum (OECzey), popularmente conhecida com canela. Uma das alternati...
Universidade Federal Cear?. Faculdade de Medicina. Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand. Fortaleza, CE, Brasil.; Universidade Federal Cear?. Faculdade de Medicina. Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand. Fortaleza, CE, Brasil.; Universidade Federal Cear?. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.; Universidad...
Federal University of Cear?. School of Medicine. Department of Pathology and Legal Medicine. Fortaleza, CE, Brazil.; Federal University of Cear?. School of Medicine. Department of Pathology and Legal Medicine. Fortaleza, CE, Brazil.; Federal University of Cear?. School of Medicine. Department of Pathology and Legal Medicine. Fortaleza, CE, Brazil.; Cear? State University. Center for Health Sciences. Fortaleza,C...