10 documents found, page 1 of 1
Addressing relationship quality of people with dementia and their family carers...
Marques, Maria J.; Woods, Bob; Jelley, Hannah; Kerpershoek, Liselot; Hopper, Louise; Irving, Kate; Bieber, Anja; Stephan, Astrid; Sköldunger, AndersObjective: The quality of the relationship between persons with dementia and family carers influences health and quality-of-life outcomes. Little is known regarding those at higher risk of experiencing a decline in relationship quality, who could potentially benefit the most from interventions. We aimed to identify these risk profiles and explore the underlying factors. Methods: We applied a latent profile anal...
Needs for Care, Service Use and Quality of Life in Dementia: 12-Month Follow-Up...
Gonçalves-Pereira, Manuel; Marques, Maria J.; F. Alves, Regina; Verdelho, Ana; Balsinha, Conceição; Alves, Luísa; Alves Reis, Teresa; Woods, BobIntroduction: The intermediate stages of dementia are relatively under-researched, including in Portugal. The Actifcare (ACcess to TImely Formal Care) EU-JPND project studied people with mild-moderate dementia, namely their needs, access to and use of community services (e.g., day centers, home support). In our baseline assessment of the Portuguese Actifcare cohort, the unmet needs of some participants would ca...
Association of rare APOE missense variants V236E and R251G with risk of Alzheim...
Le Guen, Yann; Belloy, Michael E.; Grenier-Boley, Benjamin; de Rojas, Itziar; Castillo-Morales, Atahualpa; Jansen, Iris; Nicolas, AudeImportance: The APOE ε2 and APOE ε4 alleles are the strongest protective and risk-increasing, respectively, genetic variants for late-onset Alzheimer disease (AD). However, the mechanisms linking APOE to AD-particularly the apoE protein's role in AD pathogenesis and how this is affected by APOE variants-remain poorly understood. Identifying missense variants in addition to APOE ε2 and APOE ε4 could provide crit...
Trajectories of relationship quality in dementia: a longitudinal study in eight...
Marques, Maria J.; Tan, Eva Y.L.; Woods, Robert; Jelley, Hannah; Kerpershoek, Liselot; Hopper, Louise; Irving, Kate; Bieber, Anja; Stephan, AstridObjectives: Relationship quality (RQ) between a person with dementia and a family carer may influence their health and quality of life. However, evidence regarding its course and influencing factors is limited. We aimed to explore RQ trajectories in dementia, and identify predictors of change. Methods: We analysed longitudinal data from a cohort of 350 community-dwelling people with dementia and their informal ...
Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders
Manera, Valeria; Abrahams, Sharon; Agüera-Ortiz, Luis; Bremond, François; David, Renaud; Fairchild, Kaci; Gros, Auriane; Hanon, Cécile; Husain, MasudMade available in DSpace on 2019-10-06T16:50:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Motor Neurone Disease Association; Apathy is a common neuropsychiatric syndrome observed across many neurocognitive and psychiatric disorders. Although there are currently no definitive standard therapies for the treatment of apathy, nonpharmacological treatment (NPT) is often considered to be at the fo...
Needs for Care and Service Use in Dementia: Baseline Assessment of Portuguese P...
Gonçalves-Pereira, Manuel; Marques, Maria J.; Balsinha, Conceição; Fernandes, Alexandra; Machado, Ana Sá; Verdelho, Ana; Barahona-Corrêa, BernardoIntroduction: People with dementia and their relatives should have timely access to formal care in the community. The EU-Actifcare project analysed access to and use of formal services, as related to unmet needs for care. We describe the cohort study implementation and baseline results in Portugal, with a focus on needs for care and service use assessments.Material and Methods: Our convenience sample consisted ...
Necessidades de cuidados e recurso aos serviços na demência : avaliação inicial...
Pereira, Manuel Gonçalves; Marques, Maria J.; Balsinha, Conceição; Fernandes, Alexandra; Machado, Ana Sá; Verdelho, Ana; Barahona Corrêa, BernardoIntroduction: People with dementia and their relatives should have timely access to formal care in the community. The EU-Actifcare project analysed access to and use of formal services, as related to unmet needs for care. We describe the cohort study implementation and baseline results in Portugal, with a focus on needs for care and service use assessments. Material and Methods: Our convenience sample consisted...
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE) : a...
van Maurik, Ingrid S; Vos, Stephanie J.; Bos, Isabelle; Bouwman, Femke H; Teunissen, Charlotte E.; Scheltens, Philip; Barkhof, Frederik; Frolich, LutzBackground: Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. Methods: In this modelling study, we included people with mild cognitive impairment (MCI) fro...
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a ...
van Maurik, Ingrid S.; Vos, Stephanie J.; Bos, Isabelle; Bouwman, Femke H.; Teunissen, Charlotte E.; Scheitens, Philip; Barkhof, Frederik; Frolich, LutzBackground Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. Methods In this modelling study, we included people with mild cognitive impairment (MCI) from ...
Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairmen...
Vos, Stephanie J. B.; Verhey, Frans; Frölich, Lutz; Kornhuber, Johannes; Wiltfang, Jens; Maier, Wolfgang; Peters, Oliver; Rüther, Eckart; Nobili, FlavioThree sets of research criteria are available for diagnosis of Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognit...