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Preparation of coated nanoparticles for a new mucosal vaccine delivery system
Borges, Olga; Borchard, Gerrit; Verhoef, J. Coos; Sousa, Adriano de; Junginger, Hans E.It has been found that the adsorption of antigens onto chitosan particles is an easy and unique mild loading process suitable to be used with vaccines. In order to increase the stability of this particles and to prevent an immediate desorption in gastrointestinal fluids, a coating process with sodium alginate was developed. One of the challenges of this developing process was to keep the particles in the nanosi...
Date: 2005
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Origin: Estudo Geral - Universidade de Coimbra