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Early alveolar macrophage response and IL-1R-dependent T cell priming determine...
Lovey, Arianne; Verma, Sheetal; Kaipilyawar, Vaishnavi; Ribeiro-Rodrigues, Rodrigo; Husain, Seema; Palaci, Moises; Dietze, Reynaldo; Ma, ShuyiFunding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision...
Transmission phenotype of mycobacterium tuberculosis strains is mechanistically...
Verma, Sheetal; Bhatt, Kamlesh; Lovey, Arianne; Ribeiro-Rodrigues, Rodrigo; Durbin, Joan; Jones-López, Edward C.; Palaci, Moises; Vinhas, Solange A.In a study of household contacts (HHC), households were categorized into High (HT) and Low (LT) transmission groups based on the proportion of HHC with a positive tuberculin skin test. The Mycobacterium tuberculosis (Mtb) strains from HT and LT index cases of the households were designated Mtb-HT and Mtb-LT, respectively. We found that C3HeB/FeJ mice infected with Mtb-LT strains exhibited significantly higher b...