8 documents found, page 1 of 1

The Impact of Multidisciplinary Team Conferences in Urologic Cancer in a Tertia...

Purpose: Multidisciplinary team (MDT) conferences are currently the standard of care in cancer patients' management. Despite evidence supporting benefits to the majority of malignancies, a paucity of data exists examining the impact in urinary and male genital cancers. This study aims to evaluate the impact of MDT conferences in urologic cancer practice. Methods: Clinical plans discussed in urologic MDT confere...

A Gencitabina como Alternativa Terapêutica na Ausência de BCG: A Experiência do...

Introdução: Os tumores não músculo invasivos da bexiga devem ser estratificados em grupos de risco de forma a adequar o tratamento após cirurgia a cada doente. Nos tumores de alto risco deve ser realizada terapêutica adjuvante com bacilo de Calmette-Guérin (BCG) intravesical durante 1 a 3 anos. Têm sido reportadas roturas de stock de BCG intravesical, tendo sido o Centro Hospitalar de Lisboa Central (CHLC) afec...

EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Dis...

BACKGROUND: There are no prognostic factor publications on stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with 1-3 yr of maintenance bacillus Calmette-Guérin (BCG). OBJECTIVE: To determine prognostic factors in NMIBC patients treated with 1-3 yr of BCG after transurethral resection of the bladder (TURB), to derive nomograms and risk groups, and to identify high-risk patients who should be consid...

Locally Advanced and Metastatic Prostate Cancer Treated with Intermittent Andro...

BACKGROUND: Few randomised studies have compared antiandrogen intermittent hormonal therapy (IHT) with continuous maximal androgen blockade (MAB) therapy for advanced prostate cancer (PCa). OBJECTIVE: To determine whether overall survival (OS) on IHT (cyproterone acetate; CPA) is noninferior to OS on continuous MAB. DESIGN, SETTING, AND PARTICIPANTS: This phase 3 randomised trial compared IHT and continuous MAB...

Sialyl Tn-Expressing Bladder Cancer Cells Induce a Tolerogenic Phenotype in Inn...

Despite the wide acceptance that glycans are centrally implicated in immunity, exactly how they contribute to the tilt immune response remains poorly defined. In this study, we sought to evaluate the impact of the malignant phenotype-associated glycan, sialyl-Tn (STn) in the function of the key orchestrators of the immune response, the dendritic cells (DCs). In high grade bladder cancer tissue, the STn antigen ...

The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

Rastreio do Cancro da Próstata

Diagnóstico do Cancro da Bexiga

Exame físico (incluindo toque rectal). Ultrasonografia renal e da bexiga e/ou UIV Cistoscopia com descrição de tamanho, e localização do tumor (o diagrama da bexiga deve ser incluído). Urina Tipo II; Citologia urinária, RTU com biópsia da base tumoral. Biópsias de todas as áreas suspeitas; biópsias randomizadas na presença da citologia positiva, tumor >3cm, ou tumor não papilar; biópsia da uretra prostática em ...