5 documents found, page 1 of 1
A proline derivative-enriched methanol fraction from Sideroxylon obtusifolium l...
Souza, Tamiris F. G.; Pierdoná, Taiana M.; Macedo, Fernanda Soares; Aquino, Pedro E. A.; Rangel, Gisele F. P.; Duarte, Rebeca S.; Silva, Lorena Mara A.It was previously demonstrated that the methanol fraction of Sideroxylon obtusifolium (MFSOL) promoted anti-inflammatory and healing activity in excisional wounds. Thus, the present work investigated the healing effects of MFSOL on human keratinocyte cells (HaCaT) and experimental burn model injuries. HaCaT cells were used to study MFSOL’s effect on cell migration and proliferation rates. Female Swiss mice were...
Rapid and long-lasting antidepressant-like effects of ketamine and their relati...
Viana, Glauce S. B.; Vale, Eduardo Mulato do; Araujo, A. R. A. de; Coelho, N. C.; Andrade, S. M.; Costa, R. O. da; Aquino, Pedro Everson Alexandre deKetamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
Spondias mombin: Quality control and anti-inflammatory activity in human neutro...
Silva, Thiala S. J. da; Soares, Arlete A.; Rocha, Talita M.; Pimenta, Antônia T. Á.; Miron, Diogo; Silva, Rolf J. F.; Viana, Glauce S. B.Spondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin lea...
Neuroprotective properties of the standardized extract from Camellia sinensis (...
Pinto, Natália Bitu Pinto,; Alexandre, Bruno da Silva Alexandre; Neves, Kelly Rose Tavares; Silva, Aline Holanda; Leal, Luzia Kalyne Almeida MoreiraCamellia sinensis (green tea) is largely consumed, mainly in Asia. It possesses several biological effects such as antioxidant and anti-inflammatory properties. The objectives were to investigate the neuroprotective actions of the standardized extract (CS), epicatechin (EC) and epigallocatechin gallate (EGCG), on a model of Parkinson’s disease. Male Wistar rats were divided into SO (sham-operated controls), unt...
Avaliação da administração crônica de Mucuna pruriens sobre parâmetros bioquími...
Lopes, Amanda A.; Pereira, Fábio A.; Queiroz, Maria Goretti Rodrigues de; Pitombeira, Márcia V.; Leal, Luzia Kalyne Almeida Moreira; Viana, Glauce S. B.Parkinson’s disease (PD) is a neurodegenerative disease that causes a selective loss of dopaminergic neurons in the substantia nigra. The cardinal signals of the disease are bradykinesia, resting tremor and postural instability. It is the second most common neurodegenerative disease, after Alzheimer’s disease, for which there is no neurorestorative treatment. Mucuna pruriens is used in traditional medicine espe...