20 documents found, page 1 of 2
The medicinal species Myracrodruon urundeuva Fr. All. presents antidiabetic and...
Moreira, Alisson Cordeiro; Moreira, Ítalo Cordeiro; Alves, Viviane de Jesus; Carvalho, José Bégue Moreira; Lopes, Maria Janice PereiraThe Type 2 diabetes (T2D) is a global epidemics and considered as an inflammation related disease. Myracrodruon urundeuva (Anacardiaceae) is used in Northeast Brazil, because of its anti-inflammatory properties. The species is known to present tannins and chalcones among its active compounds. The objectives of the work were to investigate the antidiabetic and hypolipidemic activities of the stem bark decoction ...
Spirulina platensis alleviates the liver, brain and heart oxidative stress in T...
Garcia, Francisca Adilfa de Oliveira; Yuen, Violet G.; Campos, Helioswilton Sales de; Turatti, Eveline; Viana, Glauce Socorro de BarrosSpirulina platensis (SPI) is a microalga with a high content of functional compou nds, such as phenolics, phycocyanins and polysaccharides that has been shown to have antioxidant, anti - inflammatory, hypoglycemic, neuroprotective and immunomodulatory effects. The objectives of the present work were to study the possible effects of SPI treatment on the glycemic -lipid profile, oxid a- tive stress, lipid peroxid...
The treadmill exercise protects against dopaminergic neuron loss and brain oxid...
Costa, Roberta Oliveira da; Gadelha-Filho, Carlos Vinicius Jataí; Costa, Ayane Edwiges Moura da; Feitosa, Mariana Lima; Araújo, Dayane Pessoa deParkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. ...
Doxycycline induces bone repair and changes in Wnt signalling
Gomes, Kátia do Nascimento; Alves, Ana Paula Negreiros Nunes; Dutra, Paula Góes Pinheiro; Viana, Glauce Socorro de BarrosDoxycycline (DOX) exhibits anti-in fl ammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls (CTL) and DOX-treated (10 and 25 mg . kg − 1 ) molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays. Hematoxylin-eosin staining (7th day)...
Himatanthus drasticus : a chemical and pharmacological review of this medicinal...
Almeida, Sheyla Cristina Xenofonte de; Monteiro, Álefe Brito; Costa, Galberto Martins da; Viana, Glauce Socorro de BarrosIn order to compile the empirical use, as well as the chemical, pharmacological and biological aspects of Himatanthus drasticus (Mart.) Plumel, Apocynaceae, a review was carried out by searching PubMed, Google Scholar, Scientific Electronic Online Library, Web of Science, Science Direct, Scopus and Cochrane. For that, works in English, Spanish and Portuguese, preclinical studies and revisions, addressing chemic...
The anti-inflammatory effects of N-methyl-(2S,4R)- trans -4-hydroxy- l -proline...
Aquino, Pedro Everson Alexandre de; Magalhães, Talita Rocha; Nicolau, Lucas Antonio Duarte; Leal, Luzia Kalyne Almeida MoreiraBackground Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic. Purpose To evaluate the anti-inflammatory properties of the N-methyl-(2S,4R)-trans-4-hydroxy-l-proline (NMP) from S. obtusifolium leaves in models of inflammation and to clarify its action me...
Pentoxifylline neuroprotective effects are possibly related to its anti-inflamm...
Neves, Kelly Rose Tavares; Nobre Júnior, Hélio Vitoriano; Leal, Luzia Kalyne Almeida Moreira; Andrade, Geanne Matos de; Brito, Gerly Anne de CastroPentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action. Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD. Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, rece...
Curcumin reversion of neurochemical and immunohistochemical alterations in brai...
Lucetti, Elaine Cristina Pereira; Lucetti, Daniel Luna; Ribeiro, Ana Elisa da Silva; Moura, Rafael Barbosa de; Sampaio, Thayga Maria AraújoStroke is one leading cause of mortality and morbidity worldwide where free radicals production and inflammation play important roles. Curcumin, a curcuminoid from Curcuma longa presents several biological properties and is a potent anti-inflammatory and antioxidant agent. The objectives were to study the neuroprotective effects of curcumin on ischemic pups from mothers treated with this drug (25, 50 or 100 mg/...
Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the P...
Correia, Alyne Oliveira; Cruz, Abílio Augusto Pimentel; Aquino, Arôdo Tenório Ribeiro de; Diniz, Joanisson Rubens GomesPiperine (PIP), an alkaloid from the Piper genus plants, presents biological properties, including potent anti-inflammatory actions. Since neuroinflammation plays a key role in Parkinson's disease (PD), the objectives were to evaluate the neuroprotective activity of PIP in a model of PD. Male Wistar rats were divided as: sham-operated (SO), untreated 6-OHDA (lesioned in the right striatum) and 6-OHDA lesioned a...
Omega-3 fatty acids : possible ceuroprotective mechanisms in the model of globa...
Nobre, Maria Elizabeth Pereira; Correia, Alyne Oliveira; Mendonça, Francisco Nilson Maciel; Uchoa, Luiz Ricardo AraújoBackground. Omega-3 (3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic an...