2 documents found, page 1 of 1
Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
Nóbrega, Otávio T.; Morais-Junior, Gilberto S.; Viana, Nayara I.; Reis, Sabrina T.; Perez, Diego I. V.; Freitas, Wladimir M.; Sposito, Andrei C.Made available in DSpace on 2022-04-28T19:28:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; The human aging is marked by several body changes, including in bone mineral density (BMD). Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute an...
Prima-1 induces apoptosis in bladder cancer cell lines by activating p53
Piantino, Camila B.; Reis, Sabrina T.; Viana, Nayara I.; Silva, Iran A.; Morais, Denis R.; Antunes, Alberto A.; Dip, Nelson; Srougi, MiguelOBJECTIVES: Bladder cancer represents 3% of all carcinomas in the Brazilian population and ranks second in incidence among urological tumors, after prostate cancer. The loss of p53 function is the main genetic alteration related to the development of high-grade muscle-invasive disease. Prima-1 is a small molecule that restores tumor suppressor function to mutant p53 and induces cancer cell death in various canc...