Encontrados 10 documentos, a visualizar página 1 de 1
Reconstruction and exploitation of a dedicated Genome-Scale Metabolic Model of ...
Viana, Romeu; Couceiro, Diogo; Newton, William; Coutinho, Luís; Dias, Oscar; Coelho, Carolina; Teixeira, Miguel CachoC. neoformans is notorious for causing severe pulmonary and central nervous system infections, particularly in immunocompromised patients. High mortality rates, associated with its tropism and adaptation to the brain microenvironment and its drug resistance profile, makes this pathogen a public health threat and a World Health Organization (WHO) priority.In this study, we reconstructed GSMM iRV890 for C. neofor...
Unveiling new features of the human pathogen Cryptococcus neoformans through th...
Viana, Romeu; Couceiro, Diogo; Newton, William; Coutinho, Luís; Dias, Oscar; Coelho, Carolina; Teixeira, Miguel CachoCryptococcus neoformans is notorious for causing severe pulmonary and central nervous system infections, particularly in immunocompromised patients. High mortality rates, associated with its tropism and adaptation to the brain microenvironment and its drug resistance profile, make this pathogen a public health threat and a World Health Organization (WHO) priority. This study presents the first reconstructed gen...
Metabolic reconstruction of the human pathogen Candida auris: using a cross-spe...
Viana, Romeu; Carreiro, Tiago; Couceiro, Diogo; Dias, Oscar; Rocha, I.; Teixeira, Miguel CachoCandida auris is an emerging human pathogen, associated with antifungal drug resistance and hospital candidiasis outbreaks. In this work, we present iRV973, the first reconstructed Genome-scale metabolic model (GSMM) for C. auris. The model was manually curated and experimentally validated, being able to accurately predict the specific growth rate of C. auris and the utilization of several sole carbon and nitro...
Marine Sponge and Octocoral-Associated Bacteria Show Versatile Secondary Metabo...
Almeida, João F; Marques, Matilde S.; Oliveira, Vanessa; Egas, Conceição; Mil-Homens, Dalila; Viana, Romeu; Cleary, Daniel F. R.; Huang, Yusheng MMarine microbiomes are prolific sources of bioactive natural products of potential pharmaceutical value. This study inspected two culture collections comprising 919 host-associated marine bacteria belonging to 55 genera and several thus-far unclassified lineages to identify isolates with potentially rich secondary metabolism and antimicrobial activities. Seventy representative isolates had their genomes mined f...
A genome-scale metabolic model for the human pathogen Candida Parapsilosis and ...
Viana, Romeu; Couceiro, Diogo; Carreiro, Tiago; Dias, Oscar; Rocha, Isabel; Teixeira, Miguel CachoCandida parapsilosis is an emerging human pathogen whose incidence is rising worldwide, while an increasing number of clinical isolates display resistance to first-line antifungals, demanding alternative therapeutics. Genome-Scale Metabolic Models (GSMMs) have emerged as a powerful in silico tool for understanding pathogenesis due to their systems view of metabolism, but also to their drug target predictive cap...
Drug Target Identification based on the construction of a Genome-scale metaboli...
Couceiro, Diogo; Viana, Romeu; Carreiro, Tiago; Dias, Oscar; Rocha, Isabel; Teixeira, Miguel C.Candida parapsilosis has seen one of the most significant rises in incidence among pathogenic Candida spp., often taking second place only to C. albicans 1. Addingto this increased incidence is the rise in resistance to first line antifungals and lack ofadequate alternative therapeutics, not only for C. parapsilosis but throughout the genus 2,3. Genome Scale Metabolic Models (GSMMs) have risen as a powerful in ...
Marine sponge and octocoral-associated bacteria show versatile secondary metabo...
Almeida, João F.; Marques, Matilde; Oliveira, Vanessa; Egas, Conceição; Mil-Homens, Dalila; Viana, Romeu; Cleary, Daniel F. R.; Huang, Yusheng M.Marine microbiomes are prolific sources of bioactive natural products of potential pharmaceutical value. This study inspected two culture collections comprising 919 host-associated marine bacteria belonging to 55 genera and several thus-far unclassified lineages to identify isolates with potentially rich secondary metabolism and antimicrobial activities. Seventy representative isolates had their genomes mined f...
A computational approach to finding new drug targets for pathogenic Candida spe...
Viana, Romeu; Couceiro, Diogo; Carneiro, Tiago; Souza, Caio; Dias, Oscar; Rocha, Isabel; Soares, Cláudio; Teixeira, Miguel C.Candida species are among the most impactful fungal pathogens, normally associated with very high mortality rates. With the rise in frequency of multidrug-resistant clinical isolates, the identification of new drug targets and new drugs is crucial to overcome the increase in therapeutic failure. In this study, we present the first validated genome-scale metabolic models for three pathogenic Candida species, Can...
Genome-scale metabolic model of the human pathogen Candida albicans: a promisin...
Viana, Romeu; Dias, Oscar; Lagoa, Davide Rafael Santos; Galocha, Mónica; Rocha, Isabel; Teixeira, Miguel CachoCandida albicans is one of the most impactful fungal pathogens and the most common cause of invasive candidiasis, which is associated with very high mortality rates. With the rise in the frequency of multidrug-resistant clinical isolates, the identification of new drug targets and new drugs is crucial in overcoming the increase in therapeutic failure. In this study, the first validated genome-scale metabolic mo...
Genome-scale metabolic model of the human pathogen C. albicans: aiming the iden...
Viana, Romeu; Dias, Oscar; Bastos, José; Lagoa, Davide Rafael Santos; Galocha, Mónica; Rocha, I.; Teixeira, Miguel CachoCandida albicans is the most common cause of invasive candidiasis, partly due to its ability to acquire drug resistance. With the rise in frequency of multidrug resistant clinical isolates, therapeutic options are running low. The identification of new drug targets and new drugs is crucial to overcome the increase in therapeutic failure. Currently, genome-scale metabolic models can be considered established too...