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In vitro and in vivo evaluation of quinones from Auxemma oncocalyx Taub. on Lei...
Viana, Sayonara de Melo; Ferreira, Maria Augusta D.; Guerra, Priscila Valera; Viana, Glauce S. Barros; Teixeira, Maria JaniaThe effect of a quinone fraction (QF) isolated from the heartwood of Auxemma oncocalyx Taub. was investigated in vitro and in vivo on Leishmania braziliensis . Although QF (1-10 μ g/mL) showing marked in vitro anti- Leishmania activity (81 to 94%), the oral treatment with the compound did not protect hamsters against progressive L. braziliensis infection. When QF was administered intraperitoneally (20 mg/kg) th...
Persistência da infecção por Leishmania braziliensis em camundongos BALB/c medi...
Viana, Sayonara de MeloLeishmania braziliensis is the main causative agent of American cutaneous leishmaniasis in Brazil. Altough L. braziliensis infection is self-limited it is distinguished by its latency and chronicity and can persist in mice and patients even after spontaneous clinical cure or treatment. Little is known about the persistence feature in L. braziliensis’ infection in humans and mice. Thereby, the aim of this study ...