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Comparison of accuracy in 2D and 3D templates in total knee arthroplasty
Viana, Tânia; Faria, Brígida Mónica; Faria, Brigida MonicaTotal knee arthroplasty replaces damaged components with prostheses, often used to treat severe osteoarthritis or joint injuries. Advances such as digital templating improve preoperative planning, reducing errors and costs, but accuracy in the choice of implants is crucial to the success of the intervention. This study will compare the accuracy between three-dimensional (3D) and two-dimensional (2D) templating ...
3D printed Poly(ε-caprolactone)/Hydroxyapatite scaffolds for bone tissue engine...
Biscaia, Sara; Branquinho, Mariana V.; Alvites, Rui D.; Fonseca, Rita; Sousa, Ana Catarina; Pedrosa, Sílvia Santos; Caseiro, Ana R.; Guedes, FernandoBone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. Polycaprolactone-based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated so as to improve the scaffolds’ mechanical properties and tissue in-growth. In this study, hydroxyapatite is incorporated on polycaprolactone...
Additive manufactured Poly("-caprolactone)-graphene scaffolds: Lamellar crystal...
Biscaia, Sara; Silva, João C.; Moura, Carla; Viana, Tânia; Tojeira, Ana; Mitchell, Geoffrey R.; Pascoal-Faria, Paula; Ferreira, Frederico CasteloUnderstanding the mechano–biological coupling mechanisms of biomaterials for tissue engineering is of major importance to assure proper scaffold performance in situ. Therefore, it is of paramount importance to establish correlations between biomaterials, their processing conditions, and their mechanical behaviour, as well as their biological performance. With this work, it was possible to infer a correlation be...
3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engine...
Biscaia, Sara; Branquinho, Mariana V.; Alvites, Rui D.; Fonseca, Rita; Sousa, Ana Catarina; Pedrosa, Sílvia Santos; Caseiro, Ana R.; Guedes, FernandoBone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. Polycaprolactone-based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated so as to improve the scaffolds’ mechanical properties and tissue in-growth. In this study, hydroxyapatite is incorporated on polycaprolactone...
Development of novel 3D scaffolds using BioExtruder by varying the content of h...
Pattanashetti, Nandini A.; Viana, Tânia; Alves, Nuno; Mitchell, Geoffrey; Kariduraganavar, Mahadevappa Y.Polycaprolactone (PCL) is considered as a most widely used biodegradable polymers in tissue engineering. But, PCL is also associated with certain limitations like, low stiffness, hydrophobic nature and limited cell affinity. These drawbacks are addressed in the present study by incorporating different wt% of silicon dioxide (SiO2) and hydroxyapatite (HAp) in the PCL matrix. 3D scaffolds were developed using a n...
Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogel...
Lopes, João; Fonseca, Rita; Viana, Tânia; Fernandes, Cristiana; Morouço, Pedro; Moura, Carla; Biscaia, SaraTissue Engineering depends on broadly techniques to regenerate tissues and/or organ functions. To do so, tailored polymeric and/or hydrogel scaffolds may be used to ensure the appropriate regeneration. Hydrogels are suitable materials for constructing cell-laden matrices as they can be produced with incorporation of cells and rapidly cross-linked in situ through photopolymerisation reactions. Measurement of the...
Rosin Based Composites for Additive Manufacturing
Sousa, Dora; Biscaia, Sara; Viana, Tânia; Gaspar, Miguel Belbut; Mahendra, Vidhura; Mohan, Saeed D.; Mateus, Artur; Mitchell, GeoffreyRosins are the non-volatile exudates of pine resins with hydrophobic characteristics that are widely used as a precursor for many industrial applications. In this paper we discuss the nature, process and its applications as a matrix for a composite material for additive manufacturing. The composite material has been tailored to chemical and mechanical properties with respect to their applications.
Tools to define and evaluate morphology mapping, a route to complex structures ...
Pinheiro, João; Abdulghani Oliveira da Silva, Saba; Pascoal-Faria, Paula; Sousa, Dora; Carreira, Pedro; Viana, Tânia; Kamma-Lorger, Christina S.Direct Digital Manufacturing is a new set of technologies which allow objects to be printed directly from a digital definition. Such technologies allow us to manufacture any self-supporting shape, but simply replicating shape is not sufficient for the production of many parts especially those with specific function. We need to be able to generate complex multiscale structures similar to those we observe in natu...
Poly(ɛ-caprolactone) and Polyethylene Glycol Diacrylate-based Scaffolds for TMJ...
Francisco, Luís; Moura, Carla; Viana, Tânia; Ângelo, David; Morouço, Pedro; Alves, NunoThe temporomandibular joint (TMJ), articulation between the mandibular condyle and the temporal bone, is divided into two compartments (superior and inferior) by a fibrocartilaginous disc. The TMJ disc consists on an avascular and non-innervated tissue, with viscoelastic behavior. Mechanically, the TMJ disc experiences tensile, compressive and shear forces. TMJ disc displacement or degeneration could lead to se...
Controlled in Vitro Release of Levodopa from Sodium Alginate Membranes
Franco, Margarida; Biscaia, Sara; Viana, Tânia; Alves, Nuno; Morouço, PedroLevodopa (LD) plays a central role in Parkinson’s Disease therapeutics. In this study, we aimed to encapsulate LD in sodium alginate (SA) membranes, and to study its dissolution profiles. Two types of SA membranes, loaded with two different amounts of LD were prepared and compared (M1: 85 mg per 50 ml SA/LD; M2: 127.5 mg per 75 ml SA/LD); membranes production followed a solvent-casting methodology. Calcium chlo...