9 documents found, page 1 of 1
Rapid and long-lasting antidepressant-like effects of ketamine and their relati...
Viana,G.S.B.; Vale,E.M. do; Araujo,A.R.A. de; Coelho,N.C.; Andrade,S.M.; Costa,R.O. da; Aquino,P.E.A. de; Sousa,C.N.S. de; Medeiros,I.S. deKetamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
A proline derivative-enriched methanol fraction from Sideroxylon obtusifolium l...
Souza,T.F.G.; Pierdoná,T.M.; Macedo,F.S.; Aquino,P.E.A.; Rangel,G.F.P.; Duarte,R.S.; Silva,L.M.A.; Viana,G.S.B.; Alves,A.P.N.N.; Montenegro,R.C.It was previously demonstrated that the methanol fraction of Sideroxylon obtusifolium (MFSOL) promoted anti-inflammatory and healing activity in excisional wounds. Thus, the present work investigated the healing effects of MFSOL on human keratinocyte cells (HaCaT) and experimental burn model injuries. HaCaT cells were used to study MFSOL's effect on cell migration and proliferation rates. Female Swiss mice were...
Anti-inflammatory and antinociceptive effects of phonophoresis in animal models...
Cardoso,L.C.P.; Pinto,N.B.; Nobre,M.E.P.; Silva,M.R.; Pires,G.M.; Lopes,M.J.P.; Viana,G.S.B.; Rodrigues,L.M.R.The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in ...
In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovas...
Gonçalves,D.O.; Calou,I.B.F.; Siqueira,R.P.; Lopes,A.A.; Leal,L.K.A.; Brito,G.A.C.; Tomé,A.R.; Viana,G.S.B.Statins are among the most prescribed drugs in recent clinical practice. They are also known for their pleiotropic actions, which are independent of their lipid-lowering properties. The effect of lovastatin was investigated against carrageenan-induced paw edema in male Wistar rats (200-250 g) and on leukocyte migration, as measured by carrageenan-induced peritonitis in male Swiss mice (20-25 g), which are model...
Antinociceptive properties in mice of a lectin isolated from the marine alga Am...
Neves,S.A.; Freitas,A.L.P.; Souza,B.W.S.; Rocha,M.L.A.; Correia,M.V.O.; Sampaio,D.A.; Viana,G.S.B.The antinociceptive effects of a lectin (LEC) isolated from the marine alga Amansia multifida were determined in Swiss mice. The LEC (1, 5, and 10 mg/kg) inhibited acetic acid-induced abdominal writhings in a dose-dependent manner after intraperitoneal or oral administration. A partial but significant inhibition of writhings was observed after the combination of LEC (10 mg/kg) with avidin (1 mg/kg), a potent in...
The alga Bryothamnion seaforthii contains carbohydrates with antinociceptive ac...
Vieira,L.A.P.; Freitas,A.L.P.; Feitosa,J.P.A.; Silva,D.C.; Viana,G.S.B.Bryothamnion seaforthii, a red alga common to the Northeastern coast of Brazil, was used to prepare the protein fraction F0/60 by ammonium sulfate precipitation. The chromatography of F0/60 on DEAE-Sephadel column resulted in two lectin fractions, PI and PII, which have antinociceptive properties in rodents. We determined the antinociceptive activity of the PII fraction and of a carbohydrate-containing fraction...
Effects of chronic ethanol treatment on monoamine levels in rat hippocampus and...
Vasconcelos,S.M.M.; Cavalcante,R.A.; Aguiar,L.M.V.; Sousa,F.C.F.; Fonteles,M.M.F.; Viana,G.S.B.We studied the effects of ethanol on concentrations of noradrenaline (NE), dopamine (DA) and serotonin (5-HT) and their metabolites in rat hippocampus and striatum. Ethanol (2 or 4 g/kg, po, from a 20% aqueous solution) was administered daily to male Wistar rats (4-13 per group) for 30 days and animals were sacrificed 30 min or 48 h after the last administration. Monoamines were measured by HPLC and considered ...
Effect of one-week ethanol treatment on monoamine levels and dopaminergic recep...
Vasconcelos,S.M.M.; Macêdo,D.S.; Lima,L.O.; Sousa,F.C.F.; Fonteles,M.M.F.; Viana,G.S.B.We studied the effects of ethanol on the levels of norepinephrine, dopamine, serotonin (5-HT) and their metabolites as well as on D1- and D2-like receptors in the rat striatum. Ethanol (2 or 4 g/kg, po) was administered daily by gavage to male Wistar rats and on the 7th day, 30 min or 48 h after drug administration, the striatum was dissected for biochemical assays. Monoamine and metabolite concentrations were ...
Antinociceptive activity of sulfated carbohydrates from the red algae Bryothamn...
Viana,G.S.B.; Freitas,A.L.P.; Lima,M.M.L.; Vieira,L.A.P.; Andrade,M.C.H.; Benevides,N.M.B.We report the antinociceptive activity, determined by the writhing, formalin and hot-plate tests in mice, of crude (F0/60), lectin and carbohydrate fractions isolated by ammonium sulfate precipitation (0 to 60%) from Bryothamnion seaforthii and B. triquetrum, species of red algae. Not only fraction F0/60 but also lectins from both species significantly inhibited acetic acid-induced abdominal contractions after ...