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Plumeran alkaloids and glycosides from the seeds of aspidosperma pyrifolium mart.
Nogueira,Patrícia C. N.; Araújo,Renata M.; Viana,Glauce S. B.; Araújo,Dayane P. de; Braz Filho,Raimundo; Silveira,Edilberto R.The residual aqueous fraction of the liquid-liquid partition of the ethanol extract from seeds of Aspidosperma pyrifolium showed antinociceptive and anti-inflammatory activities in the formalin test, abdominal writhing induced by acetic acid, and paw edema induced by carrageenan. Its phytochemical analysis led to the isolation of a new alkaloid with a rearranged plumeran skeleton, the (-)-(3S,7S,21R)-rel-(3αH)-...
Cyclosporin safety in a simplified rat brain tumor implantation model
Felix,Francisco H. C.; Fontenele,Juvenia B.; Teles,Milena G.; Bezerra Neto,João E.; Santiago,Márcia H. A. M.; Picanço Filho,Roberto L.Brain cancer is the second neurological cause of death. A simplified animal brain tumor model using W256 (carcinoma 256, Walker) cell line was developed to permit the testing of novel treatment modalities. Wistar rats had a cell tumor solution inoculated stereotactically in the basal ganglia (right subfrontal caudate). This model yielded tumor growth in 95% of the animals, and showed absence of extracranial met...
Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velu...
Vasconcelos,Silvânia M. M.; Sales,Gabriel T. M.; Lima,Natália; Lobato,Rodrigo de Freitas G.; Macêdo,Danielle Silveira; Barbosa-Filho,José MariaThis work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan- and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the ...
Plantas medicinais e seus constituintes bioativos: uma revisão da bioatividade ...
Sousa,Francisca C. F.; Melo,Carla T. V.; Citó,Maria C. O.; Félix,Francisca Helvira Cavalcante; Vasconcelos,Silvânia M. M.; Fonteles,Marta M. F.A procura de novos agentes terapêuticos provenientes de plantas medicinais para doenças psiquiátricas tem progredido significativamente na última década. Isso reflete num grande número de preparações herbárias para as quais o potencial psicoterapêutico tem sido avaliado em diversos modelos animais. O intuito desta revisão é fornecer uma ampla visão das plantas medicinais que apresentam efeitos terapêuticos sign...