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A Novel BCR-ABL1 Mutation in a Patient with Philadelphia Chromosome-Positive B-...

Vinhas, R; Lourenço, A; Santos, S; Lemos, M; Ribeiro, P; Botelho de Sousa, A; Viana Baptista, P; Ramos Fernandes, A

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) represents the most common genetic subtype of adult ALL (20%-30%) and accounts for approximately 50% of all cases in the elderly. It has been considered the subgroup of ALL with the worst outcome. The introduction of tyrosine kinase inhibitors (TKIs) allows complete hematologic remission virtually in all patients, with improved disease-free...

Date: 2018   |   Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
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