9 documents found, page 1 of 1
Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with...
Pierrot-Gallo,Bruna Spinella; Vicari,Perla; Matsuda,Sandra Satiko; Adegoke,Samuel Ademola; Mecabo,Grazielle; Figueiredo,Maria StellaBACKGROUND: Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to compare the frequency of haptoglobin genotypes and the interleukin-6 and -8 concentrations in sickle cell anemia patients...
Diagnóstico diferencial da deficiência de ferro
Vicari,Perla; Figueiredo,Maria StellaA deficiência de ferro é considerada a patologia hematológica mais prevalente no homem. Assim, é fundamental a adequada identificação de suas causas, bem como a diferenciação com outras patologias distintas para adequada abordagem da deficiência de ferro. Neste artigo são brevemente descritas outras condições que podem cursar com anemia microcítica, tais como: talassemias, anemia de doença crônica, anemia sider...
Densidade mineral óssea em crianças talassêmicas: uma experiência brasileira
Vicari,Perla; Correa,Margarida M. P.; Szejnfeld,Vera L.; Figueiredo,Maria Stella; Cavalheiro,Rita de Cássia R.; Yamamoto,MihokoA osteoporose, caracterizada por aumento da fragilidade óssea e suscetibilidade a fraturas, é inversamente proporcional ao pico de massa óssea adquirido na infância. Por outro lado, a doença óssea é uma importante causa de morbidade em pacientes portadores de beta-talassemia maior (TM). Apesar de intensamente descrita em pacientes talassêmicos adultos, não existem estudos sobre as alterações de densidade óssea ...
Priapismo na doença falciforme
Vicari,Perla; Figueiredo,Maria StellaPriapismo é a complicação relativamente freqüente na doença falciforme. Consiste de ereção peniana prolongada e dolorosa, não acompanhada de desejo ou estímulo sexual, usualmente persistente por mais de quatro horas. A disfunção erétil é seqüela comum no tratamento inadequado. A forma típica de priapismo nestes pacientes é a de baixo fluxo, ocorrendo, ainda, a forma de priapismo recorrente ou stuttering. O trat...
Genetic polymorphisms of glutathione s-transferase mu1 and theta1 in patients w...
Vicari,Perla; Duch,Cibele R.; Shimmoto,Marily M. A.; Noguti,Maria Aparecida E.; Figueiredo,Maria StellaThe causes of acquired aplastic anemia (AAA) include immunologic mechanisms and oxidative DNA damage. Glutathione S-transferase (GST) plays an important role in detoxification. In humans, GST genes encode four main clones: alpha (A), mu (M), pi (P) and theta (T). Among GST genes, GST M1 and T1 have null genotypes that result in a lack of activity. The aim of this study was to investigate polymorphisms of the GS...
Regression of extramedullary hematopoiesis with hydroxyurea therapy in ß-thalas...
Vicari,Perla; Figueiredo,Maria StellaExcessive ineffective erythropoiesis in thalassemia intermedia may cause extramedullary hematopoiesis (EMH), resulting in spleen and liver enlargement or masses in several tissues, mainly paravertebrally. Other less frequent locations of diffuse compensatory EMH are kidneys, adrenal glands, breasts, spinal cord, pleura, pericardium, duramater, adipose tissue and skin, although intrathoracic extramedullary hemat...
Severe gangrene by cold agglutinemia
Vicari,Perla; Rodrigues,Celso A.; Figueiredo,Maria S.The cold agglutinin syndrome is a haemolytic disorder usually manifested by acrocyanosis and Raynaud's phenomenon. Gangrene is an uncommon complication, usually associated with infections or B-cell lymphoproliferative diseases. We present a case of fulminant gangrene of fingers, toes, and nose in a 77-year-old woman with atypical pneumonia and acute renal failure. The diagnosis of haemolytic anaemia with cold a...
Acquired hemoglobin H disease in a patient with aplastic anemia evolving into a...
Figueiredo,Maria Stella; Vicari,Perla; Kimura,Eliza Yuriko Sugano; Antunes,Sandra Vallin; Yamamoto,MihokoCONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We repor...
Septic arthritis as the first sign of Candida tropicalis fungaemia in an acute ...
Vicari,Perla; Pinheiro,Ronald Feitosa; Chauffaille,Maria de Lourdes Lopes Ferrari; Yamamoto,Mihoko; Figueiredo,Maria StellaFungal infections caused by Candida species have increased in incidence during the past two decades in England, North America and Europe. Candidal arthritis is rare in patients who are not intravenous drug users or are who not using a prostheses. We report the case of a 24-year-old man with acute lymphoid leukemia, who developed Candida tropicalis arthritis during an aplastic period after chemotherapy. This is ...