4 documents found, page 1 of 1
Effects of gamma irradiation and periodate oxidation on the structure of dextri...
Pereira, Isabel Sofia Melo; Simões, Joana; Evtyugin, Dmitry V.; Rouif, Sophie; Coimbra, Manuel A.; Domingues, M. Rosário M.; Gama, F. M.Sterilization of biomaterials by gamma irradiation should not change its structure, since this may affect also its bioactivity. In this work, dextrin and periodate-oxidized dextrin (ODEX), both irradiated and non-irradiated, were hydrolysed by -amylase and the obtained oligosaccharides were fractionated by ligand-exchange/size exclusion chromatography and analyzed by matrix-assisted laser desorption/ionization ...
Effects of gamma irradiation and periodate oxidation on the structure of dextri...
Pereira, Isabel; Simões, Joana; Evtyugin, Dmitry V.; Rouif, Sophie; Coimbra, Manuel A.; Domingues, M. Rosário M.; Gama, MiguelSterilization of biomaterials by gamma irradiation should not change its structure, since this may affect also its bioactivity. In this work, dextrin and periodate-oxidized dextrin (ODEX), both irradiated and non-irradiated, were hydrolysed by α-amylase and the obtained oligosaccharides were fractionated by ligand-exchange/size exclusion chromatography and analyzed by matrix-assisted laser desorption/ionization...
Development of a dextrin-based hydrogel for bone regeneration
Silva, Dina M.; Morgado, Daniella L.; Delair, Thierry; David, Laurent; Rouif, Sophie; López-Lacomba, José Luis; Santos, Marta; Maurício, Ana Colette[Excerpt] Bone tissue engineering is a very challenging and promising field, which handles with the limitations of bone regenerative capacity and the failure of current orthopedic implants [1]. This work describes the preparation and characterization of an injectable dextrin-based hydrogel (oDex) able to incorporate nanoparticles, cells, biomolecules or Bonelike~ granules [2]. (...)
Potential of injectable dextrin-based hydrogel for biomedical applications
Silva, Dina M.; Morgado, Daniela; Delair, Thierry; David, Laurent; Rouif, Sophie; López-Lacomba, José Luis; Maurício, Ana Colette; Santos, José D.Bone tissue engineering is a very challenging and promising field, which handles with the limitations of bone regenerative capacity and the failure of current orthopedic implants [1]. This work describes the preparation and characterization of an injectable dextrinbased hydrogel (oDex) through dextrin oxidation followed by cross-linking with a dihydrazide [2]. In vitro and in vivo experiments allowed to conclud...