3 documents found, page 1 of 1
The role of N-glycans in regulatory T cells in autoimmunity
Carneiro, P; Vicente, MM; Leite, MI; Santos, ME; Pinho, SS; Fernandes, ÂRegulatory T cells (Tregs) have a key role in the maintenance of immune tolerance and in the prevention of autoimmunity. Recent studies have shown an association between decreased Treg frequency and a deficient suppressive activity with the development of many autoimmune diseases. Although glycosylation, which consists in the addition of glycans to proteins and lipids on the cell surface, is recognized as a cri...
Glycome dynamics in T and B cell development: basic immunological mechanisms an...
Vicente, MM; Leite-Gomes, E; Pinho, SSGlycans cover the surfaces of all mammalian cells through a process called glycosylation. Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory pathways of the immune system are glycosylated. Growing evidence indicates that the development of the immune system at the origins of T and B cell development is tightly regulated by glycosylation. In this opinion, we hypoth...
Mannosylated glycans impair normal T-cell development by reprogramming commitme...
Vicente, MM; Alves, I; Fernandes, Â; Dias, AM; Santos-Pereira, B; Pérez-Anton, E; Santos, S; Yang, T; Correia, A; Münster-Kühnel, A; Almeida, ARMT-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic dev...