8 documents found, page 1 of 1
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoPublisher Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.; In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB...
Unveiling new secrets in Parkinson's disease
Chegão, Ana; Vicente Miranda, HugoFunding Information: This study was supported by iNOVA4Health UID/Multi/04462/2013 – UIDB/04462/2020 and UIDP/04462/2020 , a program financially supported by Fundação para a Ciência e a Tecnologia (FCT) / Ministério da Ciência, Tecnologia e Ensino Superior, through national funds; and by Sociedade Portuguesa de Diabetologia . AC was supported by PD/BD/136863/2018 , FCT.; We are witnessing a considerable increas...
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease...
Chegão, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido-Ferreira, Mariana; Marques-Morgado, Inês; Fernandes Gomes, BárbaraFunding Information: This study was supported by Fundação para a Ciência e Tecnologia (FCT) PTDC/NEU-OSD/5644/2014, by iNOVA4Health UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by FCT/Ministério da Ciência, Tecnologia e Ensino Superior, through national funds; and by Sociedade Portuguesa de Diabetologia. The authors were supported by: A.C. (FCT, PD/BD/136863/2018; ProRegeM – PhD programm...
Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein
Vicente Miranda, Hugo; Chegão, Ana; Oliveira, Márcia S.; Fernandes Gomes, Bárbara; Enguita, Francisco J.; Outeiro, Tiago FlemingFunding: This study was supported by Fundação para a Ciência e Tecnologia (FCT) PTDC/NEU-OSD/5644/2014 and EXPL/NEU-OSD/0606/2012. Authors were supported by: HVM (FCT, SFRH/BPD/109347/2015); MO (FCT, EXPL/ NEU-OSD/0606/2012); AC (FCT, PD/BD/136863/2018; ProRegeM—PhD program, mechanisms of disease and regenerative medicine); BFG (PTDC/NEU-OSD/5644/2014). TFO is supported an EU Joint Program—Neurodegenerative Dis...
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced ...
Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, VeraKyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer’s disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, and recent data showed that intracerebroventricular (i.c.v.) injection of KTP ameliorates memor...
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfuncti...
Hoffmann, Anna Carin; Minakaki, Georgia; Menges, Stefanie; Salvi, Rachele; Savitskiy, Sergey; Kazman, Aida; Vicente Miranda, Hugo; Mielenz, DirkCell-to-cell propagation of aggregated alpha synuclein (aSyn) has been suggested to play an important role in the progression of alpha synucleinopathies. A critical step for the propagation process is the accumulation of extracellular aSyn within recipient cells. Here, we investigated the trafficking of distinct exogenous aSyn forms and addressed the mechanisms influencing their accumulation in recipient cells....
Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's...
König, Annekatrin; Vicente Miranda, Hugo; Outeiro, Tiago FlemingFunding: Tecnologia (FCT), Portugal (SFRH/BPD/109347/ 2015; PTDC/NEU-OSD/5644/2014). TFO is supported by the DFG Center for Nanoscale Microscopy of the Brain (CNMPB) and by an EU Joint Programme – Neurodegenerative Disease Research (JPND) project (aSynProtec). The project is supported through the following funding organisations under the aegis of JPND – www.jpnd.edu (BMBF).; Parkinson's disease (PD) is a neurod...
Correction
de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M; Martinho, Renato; Munari, Francesca; Lázaro, Diana F[This corrects the article DOI: 10.1371/journal.pbio.2000374.].