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Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental p...

Adao, R; Mendes Ferreira, P; Maia Rocha, C; Santos Ribeiro, D; Rodrigues, PG; Vidal Meireles, A; Monteiro Pinto, C; Pimentel, LD; Falcao Pires, I

We have previously shown that treatment with recombinant human neuregulin-1 (rhNRG-1) improves pulmonary arterial hypertension (PAH) in a monocrotaline (MCT)-induced animal model, by decreasing pulmonary arterial remodelling and endothelial dysfunction, as well as by restoring right ventricular (RV) function. Additionally, rhNRG-1 treatment showed direct myocardial anti-remodelling effects in a model of pressur...

Date: 2019   |   Origin: Repositório Aberto da Universidade do Porto
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