22 documents found, page 1 of 3
Black-and-White Ruffed Lemur (Varecia variegata) in captivity : analysis of the...
Silva, Carolina; Requicha, João F.; Martins, José J.; Duarte, Aida; Dias, Isabel R.; Viegas, Carlos A.; Saavedra, Maria J.This study aimed to characterize the susceptibility profile to antibiotics and biofilm formation of Gram-negative bacterial isolates obtained from the oral cavity of the black-and-white ruffed lemur (Varecia variegata). From eight individuals from a zoo located in Portugal, samples of the oral microbiota were collected with sterile swabs and then placed in closed tubes with a transport medium. Culture was carri...
Preclinical and translational studies in small ruminants (sheep and goat) as mo...
Dias, Isabel R.; Camassa, José A.; Bordelo, João A.; Babo, Pedro Miguel Sousa; Viegas, Carlos A.; Dourado, N.; Reis, R. L.; Gomes, Manuela E.Purpose of the Review: This review summarizes research on the use of sheep and goats as large animal models of human osteoporosis for preclinical and translational studies. Recent Findings: The most frequent osteoporotic sheep model used is the ovariectomized sheep with 12 months post-operatively or more and the combined treatment of ovariectomized sheep associated to calcium/vitamin D-deficient diet and glucoc...
Bone turnover markers in sheep and goat: a review of the scientific literature
Camassa, José A.; Diogo, Camila C.; Sousa, Cristina P.; Azevedo, Jorge T.; Viegas, Carlos A.; Reis, R. L.; Dourado, N.; Dias, Isabel R.Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also dur...
Evaluation of bone turnover markers and serum minerals variations for predictin...
Sousa, Cristina P.; Lopez-Peña, Mónica; Guzon, Fernando M.; Abreu, Humberto V. de; Luís, Maurino R.; Viegas, Carlos A.; Camassa, José A.Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers ...
Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifesp...
Camassa, José A.; Diogo, Camila C.; Bordelo, João P. A.; Bonelli, Marília de A.; Viegas, Carlos A.; Azevedo, Jorge T.; Dourado, Nuno; Dias, Isabel R.Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it is important to have as much ...
Evaluation of a starch-based double layer scaffold for bone regeneration in a r...
Requicha, J. F.; Moura, T.; Leonor, I. B.; Martins, T.; Muñoz, F.; Reis, R. L.; Gomes, M. E.; Viegas, Carlos A.Damages in the maxillofacial bones are frequent in humans following trauma, metabolic diseases, neoplasia, or inflammatory processes. Many of the available treatments to regenerate bone are often ineffective. The goal of this work was to assess the in vivo behavior of an innovative double-layered scaffold based on a blend of starch and polycaprolactone (SPCL) that comprises a membrane obtained by solvent castin...
Bone marrow stromal cells on a three-dimensional bioactive fiber mesh undergo o...
Rodrigues, M. T.; Leonor, I. B.; Gröena, N.; Viegas, Carlos A.; Dias, I. R.; Caridade, S. G.; Mano, J. F.; Gomes, Manuela E.; Reis, R. L.Osteogenic differentiation is a tightly regulated process dependent on the stimuli provided by the micro-environment. Silicon-substituted materials are known to have an influence on the osteogenic phenotype of undifferentiated and bone-derived cells. This study aims to investigate the bioactivity profile as well as the mechanical properties of a blend of starch and poly-caprolactone (SPCL) polymeric fiber mesh ...
Serum total and bone alkaline phosphatase levels and their correlation with ser...
Sousa, Cristina P.; Azevedo, Jorge T.; Silva, Amélia M.; Viegas, Carlos A.; Reis, R. L.; Gomes, Manuela E.; Dias, Isabel R.This study aimed to assess serum total alkaline phosphatase (ALP) and its bone isoform (BALP) levels during the ageing and in different physiologic states of sheep, in order to expand the knowledge about the variation of these biomarkers over the sheep lifespan. Ninety female sheep were divided into nine groups of various ages and physiological states (dry, lactation and pregnancy). Serum ALP, BALP and mineral ...
Periodontal tissue engineering strategies based on nonoral stem cells
Requicha, J. F.; Viegas, Carlos A.; Muñoz, Fernando; Reis, R. L.; Gomes, Manuela E.Periodontal disease is an inflammatory disease which constitutes an important health problem in humans due to its enormous prevalence and life threatening implications on systemic health. Routine standard periodontal treatments include gingival flaps, root planning, application of growth/differentiation factors or filler materials and guided tissue regeneration. However, these treatments have come short on achi...
Interleukin-6 gene -174G>C and -636G>C promoter polymorphisms and prostate canc...
Magalhães, J. F.; Cortinhas, A. J.; Albuquerque, C. M.; Baptista, C. S.; Ribeiro, R.; Viegas, Carlos A.; Matos, Augusto; Machado, João; Pires, Maria A.Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes,IL-6polymorphisms may modulate PCa risk.IL-6−174 G>C (rs 1800795, also designated −236 G>C) and −636 G>C (rs 1800796, also designated −572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit stil...