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Sustainable synthesis, antiproliferative and acetylcholinesterase inhibition of...

Cabral, Rafaela G.; Viegas, Gonçalo; Pacheco, Rita; Sousa, Ana Catarina; Robalo, Maria Paula

This work describes the design, sustainable synthesis, evaluation of electrochemical and biological properties against HepG2 cell lines, and AChE enzymes of different substituted derivatives of 1,4- and 1,2-naphthoquinones (NQ). A microwave-assisted protocol was optimized with success for the synthesis of the 2-substituted-1,4-NQ series and extended to the 4-substituted-1,2-NQ family, providing an alternative a...

Date: 2023   |   Origin: Repositório Científico do Instituto Politécnico de Lisboa
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