26 documents found, page 1 of 3
Enrichment of hepatic glycogen and plasma glucose from H₂18 O informs gluconeog...
Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; Gastaldelli, AmaliaDeuterated water (2 H2 O) is a widely used tracer of carbohydrate biosynthesis in both preclinical and clinical settings, but the significant kinetic isotope effects (KIE) of 2 H can distort metabolic information and mediate toxicity. 18 O-water (H2 18 O) has no significant KIE and is incorporated into specific carbohydrate oxygens via well-defined mechanisms, but to date it has not been evaluated in any animal...
Dietary tributyrin supplementation enhances the immune and antioxidant response...
Magnoni, Leonardo Julian; Silva-Brito, Francisca; Cavalheri, Thais; Espirito-Santo, Carlos; Palma, Mariana; Ozório, Rodrigo; Panserat, StephaneDietary supplementation with tributyrin (TBT), a source of butyric acid, has been shown to improve growth performance and health status when high levels of plant ingredients are included in aquafeeds. Here, we investigated the response of rainbow trout (Oncorhynchus mykiss) to a plant-based diet supplemented with TBT aiming to improve fish performance and welfare. Juvenile rainbow trout (19.0 ± 0.19 g, mean ± S...
On the Utilization of Dietary Glycerol in Carnivorous Fish - Part I: Insights I...
Viegas, Ivan; Tavares, Ludgero C.; Plagnes-Juan, Elisabeth; Silva, Emanuel; Rito, João; Marandel, Lucie; Palma, Mariana; Ozório, Rodrigo O. A.Glycerol is the by-product of biodiesel production and its utilisation in fish feed has recently gained relevance. As an important metabolic intermediate and structural component of triacylglycerol (TAG), it is still unclear whether its supplementation affects lipid utilisation and/or deposition in different tissues. Accordingly, a set of studies was aimed to evaluate how increasing levels of dietary glycerol (...
On the Utilization of Dietary Glycerol in Carnivorous Fish—Part II: Insights In...
Viegas, Ivan; Palma, Mariana; Plagnes-Juan, Elisabeth; Silva, Emanuel; Rito, João; Henriques, Luís F.; Tavares, Ludgero C.; Ozório, Rodrigo O. A.Glycerol is the by-product of biodiesel production and its utilisation in fish feed has recently gained relevance. As an important metabolic intermediate and structural component of triacylglycerol (TAG), it is still unclear whether its supplementation affects lipid utilisation and/or deposition in different tissues. Accordingly, a set of studies was aimed to evaluate how increasing levels of dietary glycerol (...
A mechanism for red coloration in vertebrates
Toomey, Matthew B.; Marques, Cristiana I.; Araújo, Pedro M.; Huang, Delai; Zhong, Siqiong; Liu, Yu; Schreiner, Gretchen D.; Myers, Connie A.Red coloration is a salient feature of the natural world. Many vertebrates produce red color by converting dietary yellow carotenoids into red ketocarotenoids via an unknown mechanism. Here, we show that two enzymes, cytochrome P450 2J19 (CYP2J19) and 3-hydroxybutyrate dehydrogenase 1-like (BDH1L), are sufficient to catalyze this conversion. In birds, both enzymes are expressed at the sites of ketocarotenoid bi...
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Weste...
Amorim, Ricardo; Simões, Inês C. M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; Tavares, Ludgero C.Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although the pathophysiologic mechanisms underlying disease are not fully clarified, mitochondrial dysfunction and oxidative stress are key players in disease progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment are underw...
Carbohydrate tolerance in Amazon tambaqui (Colossoma macropomum) revealed by NM...
Ferrari, Jeisson Emerson Casimiro [UNESP]; Palma, Mariana; Carli, Gabriela Castellani [UNESP]; Satiro, Thaise Mota [UNESP]; Tavares, Ludgero C.Made available in DSpace on 2022-04-29T08:36:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01; European Regional Development Fund; Fundação para a Ciência e a Tecnologia; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); In the present study, two ...
Digesta and Plasma Metabolomics of Rainbow Trout Strains with Varied Tolerance ...
Palma, Mariana; Bledsoe, Jacob W; Tavares, Ludgero C.; Romano, Nicholas; Small, Brian C.; Viegas, Ivan; Overturf, KenThe replacement of fishmeal in aquafeeds is essential to the sustainability of aquaculture. Besides the procurement of alternative protein sources, fish can also be selected for better performance on plant-based alternative diets. Rainbow trout (Oncorhynchus mykiss) is one such species in which the strain ARS-Sel has been selected for higher growth and enhanced utilization when fed soy-based diets. The aim of t...
Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed ...
Palma, Mariana; Trenkner, Lauren H.; Rito, João; Tavares, Ludgero C.; Silva, Emanuel; Glencross, Brett D.; Jones, John Griffith; Wade, Nicholas M.Practical diets for commercial barramundi production rarely contain greater than 10% starch, used mainly as a binding agent during extrusion. Alternative ingredients such as digestible starch have shown some capacity to spare dietary protein catabolism to generate glucose. In the present study, a carnivorous fish species, the Asian seabass (Lates calcarifer) was subjected to two diets with the same digestible e...
Hepatic Glycerol Metabolism-Related Genes in Carnivorous Rainbow Trout (Oncorhy...
Panserat, Stephane; Plagnes-Juan, Elisabeth; Gazzola, Elsa; Palma, Mariana; Magnoni, Leonardo J.; Marandel, Lucie; Viegas, IvanGlycerol metabolism in rainbow trout is poorly studied even though it is at the interface between lipid and glucose metabolism. Moreover, glycerol can be an important ingredient in new aquafeed formulation to decrease the catabolism of dietary amino acids. Thus, the present study aimed to characterize for the first time the different genes coding for key enzymes and proteins involved in hepatic glycerol metabol...