4 documents found, page 1 of 1
Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis
Santarino, Inês; Viegas, Michelle; Domingues, Neuza S.; Ribeiro, Ana M.; Soares, Miguel P.; Vieira, Otília V.Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Here, we report that besides recruitment of microtubule-associated protein-1-light chain 3 (LC3), addi...
The role of the endocytic and autophagic molecular machineries in the removal o...
Viegas, MichelleTese de doutoramento em Biociências, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra; Every day the human body turns over billions of cells ensuring the disposal of unwanted targets that die by apoptosis. The prompt and efficient removal of apoptotic cells by cell line (vascular SMC). The maturation of phagosomes containing dying cells was compared with the processing of phagosomes l...
Comparison of the kinetics of maturation of phagosomes containing apoptotic cel...
Viegas, Michelle; Estronca, Luís M. B. B.; Vieira, Otília V.Defective clearance of apoptotic cells has emerged as an important contributing factor to the pathogenesis of many diseases. Although many efforts have been made to understand the machinery involved in the recognition between phagocytes and potential targets, little is known about the intracellular transport of phagosomes containing apoptotic cells within mammalian cells. We have, therefore, performed a detaile...
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
Ferreira, Raquel; Santos, Tiago; Viegas, Michelle; Cortes, Luísa; Bernardino, Liliana; Vieira, Otília V.; Malva, João O.Background: Neuropeptide Y (NPY) is emerging as a modulator of communication between the brain and the immune system. However, in spite of increasing evidence that supports a role for NPY in the modulation of microglial cell responses to inflammatory conditions, there is no consistent information regarding the action of NPY on microglial phagocytic activity, a vital component of the inflammatory response in bra...