50 documents found, page 1 of 5
Physiologically based toxicokinetic models in aggregate exposure: A review
Lamon, L.; Paini, A.; Siccardi, M.; Doyle, J.; McNamara, C.; Galea, K.S.; Ghosh, M.; Louro, Henriqueta; Silva, Maria Joao; El Yamani, N.; Dusinska, M.This literature review explores the application of Physiologically Based Kinetic (PBK) models in aggregate exposure (AE) assessment across different chemical classes. It builds on the screening of 1119 publications and the identification of 40 relevant articles. The most frequently studied chemicals include volatile organic compounds and plant protection products, with metals, personal care products, persistent...
A roadmap for a 21st century human biomonitoring toolbox
Zare Jeddi, Maryam; Conrad, A.; Kolossa-Gehring, M.; Hopf, N.; Viegas, S.; Pasanen-Kase, R.; Sepai, O.; Galea, K.S.; Cubadda, F.; Louro, HenriquetaCurrent challenges in data comparability, integration, and management, hinder effective utilization of the large amount of data generated in environment and health studies. The European chapter of the International Society of Exposure Science (ISES Europe) Human Biomonitoring (HBM) Working Group is developing a global preregistration platform “FAIR Environment and Health Registry (FAIREHR)” to address these cha...
The HBM4EU e-waste study: exploratory survey of worker’s exposure to toxic cont...
Scheepers, Paul; Viegas, S.; Duca, R.C.; Cseresznye, A; Cleys, P.; Covaci, A.; Goën, T.; Galea, K.S.; Godderis, L.; Hardy, E.; Leese, E.So far, human biomonitoring (HBM) has not been much used to study exposure of workers involved in the processing of e-waste in the EU. In this study we aimed to explore exposures of workers to chemical contaminants, contribute to raise awareness of potential hazards and to further improve work practices. The study was conducted in eight European counties in a target population of 195 exposed and 73 controls. Bi...
HBM4EU chromates study: untargeted metabolomics study of workers exposed to hex...
Kozłowska, Lucyna; Santonen, T.; Duca, R.C.; Godderis, L.; Jagiello, K.; Janasik, B.; Van Nieuwenhuyse, A.; Poels, K.; Puzyn, T.; Scheepers, P.Due to the wide use of Cr(VI), a large number of workers in a variety of industries are ex-posed to the potential harmful effects of this compound. The aim of this study was to inves-tigate changes in metabolic pathways in response to Cr(VI) exposure and to search for new urinary biomarkers. The study included 220 male workers who were exposed to Cr(VI) (through welding, chromium plating, surface treatment) and...
HBM4EU diisocyanates study – results from a collaborative European human biolog...
Jones, Kate; Galea, K.S.; Scholten, B.; Loikala, M.; Porras, S.P.; Bousoumah, R.; Ndaw, S.; Leese, E.; Louro, Henriqueta; Silva, Maria João; Viegas, S.Diisocyanates have long been a leading cause of occupational asthma in Europe, and they are now restricted under the REACH regulation. As part of the European Human Biomonitoring project (HBM4EU), we conducted an occupational exposure survey on diisocyanates in five European countries. 116 workers were recruited across four job categories: (1) Use of diisocyanates-based glues, adhesives or sealants; (2) Polyure...
Effect biomarkers in e-waste management workers
Silva, Maria João; Aimonen, K.; Louro, Henriqueta; Tavares, A.; Moreira, R.; Catalan, J.; Duca, R.C.; Godderis, L.; Mahiout, S.; Martins, C.During e-waste handling/processing, a broad range of toxic chemicals (metals and persistent organic compounds), are released and may affect workers’ health. This work intended to identify genotoxic effects in workers from European e-waste management companies. Micronuclei were analysed in peripheral blood lymphocytes (MNPBL) from 95 workers and 50 controls and in reticulocytes (MNRET) from 82 workers and 41 con...
Genotoxicity in peripheral blood leukocytes and reticulocytes of e-waste manage...
Aimonen, K.; Silva, Maria João; Tavares, Ana; Moreira, Rodrigo; Louro, Henriqueta; Catalán, J.; Duca, R.; Godderis, L.; Mahiout, S.; Martins, C.The European Commission has recently adopted a new Circular Economy Action Plan, which recognizes the critical role of material circulation in achieving sustainable development. The waste management sector will play a pivotal role in this, and an increase in the number of workers involved in waste recycling is expected. However, a recent multi-centric study conducted as part of the European Human Biomonitoring ...
Unlocking the Potential of Environmental and Health Research with FAIREHR
Zare Jeddi, Maryam; Hopf, N.; Louro, Henriqueta; Silva, Maria João; Costa, Carla; Viegas, S.; Scheepers, P.; Cubadda, F.; Ghosh, M.; Ali, I.Current challenges in data comparability, integration, and management, hinder effective utilization of the large amount of data generated in environment and health studies. The European chapter of the International Society of Exposure Science (ISES Europe) Human Biomonitoring (HBM) Working Group is developing a global preregistration platform “FAIR Environment and Health Registry (FAIREHR)” to address these cha...
Exposure assessment of total DON in urine of Portuguese adult population under ...
Alvito, P.C.; Silva, M.J.; Viegas, S.; Vasco, E.; Martins, C.; Assunção, R.; Silva, S.; Gilles, L.; Govarts, E.; Schoeters, G.; Namorado, S.Mycotoxins are secondary metabolites of fungi that can be found in food commodities. Exposure to mycotoxins has been associated with several adverse health effects, including hepatotoxicity. nephrotoxicity, immunotoxicity, mutagenicity and carcinogenicity.As such, from a public health perspective it is important to monitor and to assess the risk associated to mycotoxins’ exposure. In the scope of the European H...
Drinking Green Tea: Despite the Risks Due to Mycotoxins, Is It Possible to Incr...
Assunção, Ricardo; Twarużek, M; Kosicki, R.; Viegas, C.; Viegas, S.Tea has been consumed for thousands of years. Despite the different varieties, particular emphasis has been placed on green tea (GT), considering the associated health benefits following its regular consumption, some of which are due to its polyphenol constituents, such as epigallocatechin- 3-gallate (EGCG). Tea is not prone to the growth of microorganisms, except fungus, when proper storage, handling, and pack...