25 documents found, page 1 of 3
Changes of soluble CD40 ligand in the progression of acute myocardial infarctio...
Napoleão, Patrícia; Monteiro, Maria Do Céu; Cabral, Luís B. P.; Criado, Maria Begoña; Ramos, Catarina; Selas, Mafalda; Viegas-Crespo, Ana MariaReported in vitro data implicated soluble CD40 ligand (sCD40L) in endothelial dysfunction and angiogenesis. However, whether sCD40L could exert that influence in endothelial dysfunction and angiogenesis after injury in acute myocardial infarction (AMI) patients remains unclear. In the present study, we evaluated the association of sCD40L with markers of platelet activation, endothelial, and vascular function du...
T lymphocytes alterations are associated with oxidized LDL, troponin T, white b...
Napoleão, Patrícia; Selas, Mafalda; Freixo, Cláudia; Carmo, Miguel Mota; Viegas-Crespo, Ana Maria; Ferreira, Rui Cruz; Pinheiro, TeresaBACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocy...
Influence of dyslipidemia and smoking on redox markers in humans: a critical study
Lopes, Paula Alexandra; Rodrigues, Olívia Roos; Napoleão, Patrícia; Pavão, Maria Leonor; Nève, Jean; Santos, Maria Cristina; Viegas-Crespo, Ana MariaNa actualidade, é consensual que os processos oxidativos desempenham um papel importante no aparecimento e progressão de inúmeras doenças. O conhecimento do comportamento, dos parâmetros do balanço redox, poderá surtir efeito na prevenção da ocorrência de tais patologias. OBJECTIVOS: o presente estudo numa perspectiva pioneira para uma população portuguesa (a de Lisboa) visa caracterizar a variação de parâmetro...
Blood antioxidant markers and elemental levels in Azorean patients with coronar...
Ferin, Rita; Napoleão, Patrícia; Gomes, Carla; Castro, Ana Rita; Lopes, Paula Alexandra; Martins, Dinis; Santos, Maria CristinaAtherosclerosis (ATH) and related vascular diseases are the first cause of morbidity and mortality in Portugal, including the Azores’ Archipelago. The oxidation of low density lipoproteins (LDL) is considered to be an important event in the development of the disease. Accordingly, by preventing LDL oxidation, antioxidants can possibly reduce the risk or the progression of ATH. Essential trace elements as Cu, Se...
Blood trace element levels in patients with stabilized atherosclerosis
Viegas-Crespo, Ana Maria; Napoleão, Patrícia; Lopes, Paula Alexandra; Santos, Maria Cristina; Pavão, Maria Leonor; Pinheiro, TeresaCardiovascular diseases remain the leading cause of mortality in Western populations. Dislipidemia, hypertension, diabetes, obesity and tobacco consumption are the main risk factors for atherosclerosis and its thrombotic complications. However, these factors alone cannot account for all of the deaths caused by vascular pathologies. The possible interaction of some trace element levels with atherogenic diseases ...
Antioxidant markers and cardiovascular risk factors in Azorean subjects with co...
Ferin, Rita; Gomes, Carla; Castro, Ana Rita; Martins, Dinis; Santos, Víctor; Santos, Maria Cristina; Lopes, Paula Alexandra; Baptista, JoséTo evaluate some blood antioxidant parameters in azorean subjects with coronary artery disease (CAD) previously submitted to percutaneous revascularization (PCI), by considering some cardiovascular risk factors.
Metallothionein levels in Algerian mice (Mus spretus) exposed to elemental poll...
Marques, Carla Cristina; Gabriel, Sofia Isabel; Pinheiro, Teresa; Viegas-Crespo, Ana Maria; Mathias, Maria da Luz; Bebianno, Maria JoãoThe potential use of metallothioneins (MTs) as biomarkers of trace metal contamination was evaluated for the first time in the Algerian mouse (Mus spretus). Mice were collected seasonally in an abandoned mining area (Aljustrel) and in a reference area, both located in southern Portugal. MT levels were quantified in liver and kidney by differential pulse polarography and hepatic elemental concentrations (Mn, Fe,...
Comparison of Apolipoprotein E polymorphism and other atherosclerotic risk fact...
Lopes, Paula Alexandra; Gaspar, Gisela; Napoleão, Patrícia; Santos, Maria Cristina; Pavão, Maria Leonor; Viegas-Crespo, Ana MariaO principal objectivo deste estudo é o de pesquisar o efeito da insularidade nos polimorfismos da apolipoproteína (apo) E em indivíduos saudáveis do continente (Lisboa) e de Ponta Delgada (Ilha de S. Miguel, Arquipélago dos Açores). Adicionalmente, estudar a distribuição dos seus genótipos em doentes com aterosclerose da Ilha de S. Miguel. Em Lisboa, a distribuição dos genótipos da apo E foi a seguinte: e3/e3 >...
Polymorphism of the APOE locus in the Azores Islands (Portugal)
Bettencourt, Conceição; Montiel, Rafael; Santos, Cristina; Pavão, Maria Leonor; Viegas-Crespo, Ana Maria; Lopes, Paula Alexandra; Lima, ManuelaOur aim in this study is to report on the polymorphism of the APOE gene in the Azores Islands (Portugal) to obtain a population baseline of the existing variation in this locus, known to be one of the genetic determinants of plasma lipid levels. One hundred twenty-six Azorean individuals were typed for the APOE polymorphism using standard PCR-RFLP. Allele frequencies obtained for APOE*2, APOE*3, and APOE*4 were...
Polymorphism of the ApoE locus in the Azores Islands (Portugal)
Bettencourt, Conceição; Montiel, Rafael; Santos, Cristina; Pavão, Maria Leonor; Viegas-Crespo, Ana Maria; Lopes, Paula Alexandra; Lima, ManuelaThe aim of this work was to report on the polymorphism of the ApoE locus in the Azores Islands (Portugal) in order to get insights on the genetic background that influences the lipid profile in this population, ascertained as considerably high in a preliminary study of a sample of healthy subjects (60% of individuals were hypercholesterolemics). One hundred and twenty six Azorean individuals were typed for ApoE...