3 documents found, page 1 of 1
MicroRNA‐181a restricts human γδ T cell differentiation by targeting Map3k2 and...
Gordino, Gisela; Costa‐Pereira, Sara; Corredeira, Patrícia; Alves, Patrícia; Costa, Luís; Gomes, Anita Q.; Silva‐Santos, Bruno; Ribot, Julie C.γδ T cells are a conserved population of lymphocytes that contributes to anti-tumor responses through its overt type 1 inflammatory and cytotoxic properties. We have previously shown that human γδ T cells acquire this profile upon stimulation with IL-2 or IL-15, in a differentiation process dependent on MAPK/ERK signaling. Here, we identify microRNA-181a as a key modulator of human γδ T cell differentiation. We...
MicroRNA‐181a restricts human γδ T cell differentiation by targeting Map3k2 and...
Gordino, Gisela; Costa Pereira, Sara; Corredeira, Patrícia; Alves, Patrícia; Costa, Luis; Gomes, Anita Q.; Silva-Santos, Bruno; Ribot, Julieγδ T cells are a conserved population of lymphocytes that contributes to anti-tumor responses through its overt type 1 inflammatory and cytotoxic properties. We have previously shown that human γδ T cells acquire this profile upon stimulation with IL-2 or IL-15, in a differentiation process dependent on MAPK/ERK signaling. Here, we identify microRNA-181a as a key modulator of human γδ T cell differentiation. We...
miR-181a negatively regulates human γδ T cell differentiation into anti-tumor e...
Gordino, Gisela; Pereira, Sara; Gomes, Anita Q.; silva-Santos, Bruno; Ribot, JulieCytotoxicity and IFN-γ production by human γδ T cells underlie their potent anti-tumor functions. importantly, we have previously shown that ex vivo-isolated γδ thymocytes produced negligible IFN-γ and lacked cytolytic activity against leukemia cells but could acquire those properties upon stimulation with IL-2 or IL-15. This notwithstanding, the role of post-transcriptional mechanisms mediated by miRs in the a...