40 documents found, page 1 of 4
TASTY trial: protocol for a study on the triad of nutrition, intestinal microbi...
Charneca, S; Hernando, A; Almada-Correia, I; Polido-Pereira, J; Vieira, A; Sousa, J; Almeida, AS; Motta, C; Barreto, G; Eklund, KK; Alonso-Pérez, ABackground The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). It has been proposed that gut dysbiosis impairs gut barrier function, leading to alterations in mucosal integrity and immunity. This disruption allows bacterial translocation, contributing to the perpetuation of the inflammatory process. Since diet is recognised as a key environmental factor influencing ...
Trauma Associado às Touradas à Corda nos Açores: Um Estudo Transversal
Vieira, B; Taranu, V; Vieira, A; Soares, D; Soares, A; Silva, A; Galvão, D; Bagnari, I; Melo, D; Pimentel, F; Sousa, J; Martins, L; Pinheiro, LIntroduction: The aim of the study was to describe trauma injuries associated with rope bullfights in the Azores, Portugal, regarding the cause of the incident, trauma mechanism, most affected anatomical areas, and injury severity. Methods: Two-year cross-sectional study in the local hospital with prospective data collection. Patients who were consecutively admitted to the local hospital’s emergency department ...
Planning Matters: A Document Analysis of 24 Portuguese Health Programmes
Costa, S; Morais Vilaça, I; Lima, D; Pinheiro-Guedes, L; Barbosa, S; Salvador, S; Barbabela, R; Carvalho, AC; Oliveira, P; Chaves, AC; Teixeira, MBackground: Health planning is essential for effective public health interventions and optimal resource utilisation. The Portuguese Directorate-General of Health has a long history of developing health plans and programmes, for communicable and noncommunicable diseases, and their determinants. This study aimed to review the current 24 programmes and assess the adequacy of their structure and content. Methods: A...
Multidisciplinary Development and Initial Validation of a Clinical Knowledge Ba...
Pereira, AM; Jácome, C; Jacinto, T; Amaral, R; Pereira, M; Sá-Sousa, A; Couto, M; Vieira-Marques, P; Martinho, D; Vieira, A; Almeida, A; Martins, CMost mobile health (mHealth) decision support systems currently available for chronic obstructive respiratory diseases (CORDs) are not supported by clinical evidence or lack clinical validation. The development of the knowledge base that will feed the clinical decision support system is a crucial step that involves the collection and systematization of clinical knowledge from relevant scientific sources and its...
The Impact of COVID-19 on Rare and Complex Connective Tissue Diseases: the Expe...
Talarico, R; Aguilera, S; Alexander, T; Amoura, Z; Antunes, A; Arnaud, L; Avcin, T; Beretta, L; Bombardieri, S; Burmester, G; Cannizzo, S; Cavagna, LDuring the COVID-19 pandemic, the need to provide high-level care for a large number of patients with COVID-19 has affected resourcing for, and limited the routine care of, all other conditions. The impact of this health emergency is particularly relevant in the rare connective tissue diseases (rCTDs) communities, as discussed in this Perspective article by the multi-stakeholder European Reference Network on Ra...
Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomateri...
Bettencourt, Ana; Gonçalves, L.; Gramacho, A.; Vieira, A; Rolo, D.; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Silva, Maria JoãoSeveral metallic nanomaterials (NMs), such as titanium dioxide nanomaterials (TiO2), present beneficial properties with a broad range of innovative applications. The human population is exposed to TiO2, particularly by ingestion, due to its increasing use as a food additive and inclusion in dietary supplements and food packaging materials. Whether this oral exposure may lead to adverse local or systemic outcome...
Virulence gene repression promotes Listeria monocytogenes systemic infection
Pombinho, R; Vieira, A; Camejo, A; Archambaud, C; Cossart, P; Sousa, S; Cabanes, DThe capacity of bacterial pathogens to infect their hosts depends on the tight spatiotemporal regulation of virulence genes. The Listeria monocytogenes (Lm) metal efflux pump repressor CadC is highly expressed during late infection stages, modulating lipoprotein processing and host immune response. Here we investigate the potential of CadC as broad repressor of virulence genes. We show that CadC represses the e...
Care causing diagnosis, comorbidities and nutritional status of patients in con...
Marques, M; Gonçalves, V; Vieira, A; Magalhães, F; Godinho, J; Lemos, A; Costa, V; Faria, AnaIntroduction: Poor nutritional status has negative implications on prognosis, cost of care, morbidity and mortality. However, when nutritional assessment is not implemented, malnutrition can go untreated. Objectives: The aim of this study was to establish a relationship between care causing diagnosis, existing comorbidities and nutritional status of patients admitted to a long-term care unit. Methods: In the co...
Idiopathic Inflammatory Myopathies: State of the Art on Clinical Practice Guide...
Meyer, A; Scirè, CA; Talarico, R; Alexander, T; Amoura, Z; Avcin, T; Barsotti, S; Beretta, L; Blagojevic, J; Burmester, G; Cavazzana, I; Cherrin, PIdiopathic inflammatory myopathies (IIMs) encompass a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and inflammation, but in antisynthetase syndrome arthritis and interstitial lung disease are more frequent and often inaugurate the disease. Clinical practice guidelines (CPGs) have been proposed for IIMs, but they are sparse and heterogeneous. This work aimed at identifying: i)...
Sjögren's Syndrome: State of the Art on Clinical Practice Guideline
Romão, V; Talarico, R; Scirè, CA; Vieira, A; Alexander, T; Baldini, C; Gottenberg, JE; Gruner, H; Hachulla, E; Mouthon, L; Orlandi, M; Pamfil, CSjögren's syndrome (SS) is a complex autoimmune rheumatic disease that specifically targets salivary and lachrymal glands. As such, patients typically had ocular and oral dryness and salivary gland swelling. Moreover, skin, nasal and vaginal dryness are frequently present. In addition to dryness, musculoskeletal pain and fatigue are the hallmarks of this disease and constitute the classic symptom triad presente...