5 documents found, page 1 of 1
BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases th...
Dionísio, MR; Vieira, AF; Carvalho, R; Conde, I; Oliveira, M; Gomes, M; Pinto, MT; Pereira, P; Pimentel, J; Souza, C; Marques, MMC; Silva, VDBrain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably arise by the seeding of cancer cells with stem features. Accordingly, we found that brain-tropic breast cancer cells show increased stem cell activity and ...
Pan-cancer association of a centrosome amplification gene expression signature ...
Almeida, B; Vieira, AF; Paredes, J; Bettencourt-Dias, M; Barbosa-Morais, NCentrosome amplification (CA) is a common feature of human tumours and a promising target for cancer therapy. However, CA’s pan-cancer prevalence, molecular role in tumourigenesis and therapeutic value in the clinical setting are still largely unexplored. Here, we used a transcriptomic signature (CA20) to characterise the landscape of CA-associated gene expression in 9,721 tumours from The Cancer Genome Atlas (...
SRC inhibition prevents P-cadherin mediated signaling and function in basal-lik...
Ribeiro, AS; Nobre, AR; Mendes, N; Almeida, J; Vieira, AF; Sousa, B; Carvalho, F; Monteiro, J; Polónia, A; Fonseca, M; Sanches, J; Santos, N; Seruca, RBACKGROUND: Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently overexpressed in these tumors, promoting cell invasion, stem cell activity and tumorigenesis by the activation of Src-Family kinase (SRC) signaling. Therefore, our aim was to evaluate if the trea...
Over-elongation of centrioles in cancer promotes centriole amplification and ch...
Marteil, G; Guerrero, A; Vieira, AF; Almeida, B; Machado, P; Mendonça, S; Mesquita, M; Villarreal, B; Fonseca, I; Francia, M; Dores, K; Martins, NCentrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amp...
An update on breast cancer multigene prognostic tests-emergent clinical biomarkers
Vieira, AF; Schmitt, FMultigene signatures generate crucial prognostic information particularly useful for cancer patients where clinical parameters and traditional immunohistochemical markers alone lead to equivocal prognosis. Clinicians are now provided with molecular tools that assist in the outline of adjuvant therapies, namely helping decide on the extension of adjuvant endocrine therapy or on suppressing adjuvant chemotherapy ...