16 documents found, page 1 of 2
TASTY trial: protocol for a study on the triad of nutrition, intestinal microbi...
Charneca, Sofia; Hernando, Ana; Almada-Correia, Inês; Polido Pereira, Joaquim; Vieira, Adriana; Sousa, Joana; Almeida, Ana S.; Motta, Carla MottaBackground: The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). It has been proposed that gut dysbiosis impairs gut barrier function, leading to alterations in mucosal integrity and immunity. This disruption allows bacterial translocation, contributing to the perpetuation of the inflammatory process. Since diet is recognised as a key environmental factor influencing...
Modelling Road Work Zone Crashes’ Nature and Type of Person Involved Using Mult...
Vieira, Adriana; Santos, Bertha; Picado-Santos, LuisThe sustainable development goals “Good health and well-being” and “Sustainable cities and communities” of the United Nations and World Health Organization, alert governments and researchers and raise awareness about road safety problems and the need to mitigate them. In Portugal, after the economic crisis of 2008–2013, a significant amount of road assets demand investment in maintenance and rehabilitation. The...
Forecasting daily admissions to an emergency department considering single and ...
Vieira, Adriana; Sousa, Inês; Dória-Nóbrega, SóniaWhen dealing with several years of daily data, such as the number of daily admissions to a hospital's emergency department (ED), how complex does it get to forecast into the future? With that in mind, this study has two main goals: to explore the differences between several methodologies, considering both single and multiple-seasonal patterns; and to select the most suitable model for the administration of a Po...
Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...
Vieira, Adriana; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, Lídia; Bettencourt, Ana F.; Silva, Maria JoãoAbout Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells
Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...
Vieira, Adriana; Vital, Nádia; Rolo, Dora; Roque, Rossana; Gonçalves, Lídia M.; Bettencourt, Ana; Silva, Maria João; Louro, HenriquetaThe widespread use of titanium dioxide nanomaterials (TiO2 NMs) in food and consumer products such as toothpaste or food contact materials, suggests the relevance of human oral exposure to these nanomaterials (NMs) and raises the possibility of adverse effects in the gastrointestinal tract (GIT). We previously showed that the in vitro digestion of TiO2 NMs may increase their toxicity in intestinal cells. In thi...
Cellular, Molecular and Genotoxic Effects of Digested Titanium Dioxide Nanomate...
Rolo, Dora; Pereira, Joana F.S; Vieira, Adriana; Roque, Rossana; Gramacho, Ana Catarina; Vital, Nádia; Matos, Paulo; Gonçalves, LídiaHuman exposure to titanium dioxide nanomaterials(TiO2NMs) occurs particularly by ingestion, due to food/food contact materials and consumer products. However, the possibility of adverse effects in gastrointestinal tract is unclear. Aiming to study the impact of digestion on the NMs’ properties and their cellular/molecular effects, two human intestinal cell lines were used, Caco-2 and HT29-MTX-E12. After exposur...
Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nano...
Vieira, Adriana; Gramacho, Ana; Rolo, Dora; Vital, Nádia; Silva, Maria João; Louro, HenriquetaAn exponential increase in products containing titanium dioxide nanomaterials (TiO2), in agriculture, food and feed industry, lead to increased oral exposure to these nanomaterials (NMs). Thus, the gastrointestinal tract (GIT) emerges as a possible route of exposure that may drive systemic exposure, if the intestinal barrier is surpassed. NMs have been suggested to produce adverse outcomes, such as genotoxic ef...
Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...
Vieira, Adriana; Vital, Nádia; Rolo, Dora; Roque, Rossana; Gonçalves, Lídia; Bettencourt, Ana; Silva, Maria João; Louro, HenriquetaThe widespread use of titanium dioxide nanomaterials (TiO2 NMs) in food and consumer products such as toothpaste or food contact materials, suggests the relevance of human oral exposure to these nanomaterials (NMs) and raises the possibility of adverse effects in the gastrointestinal tract (GIT). We previously showed that the in vitro digestion of TiO2 NMs may increase their toxicity in intestinal cells. In thi...
Titanium dioxide nanomaterials - induced DNA damage in intestinal cells followi...
Vieira, Adriana; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, Lídia; Bettencourt, Ana; Silva, Maria JoãoIntroduction: The increased use of titanium dioxide nanomaterials (TiO2) in food products has raised oral exposure to those nanomaterials, with subsequent risks to human health, particularly genotoxicity and, ultimately, cancer development. In humans, the digestion process may modify the physicochemical properties of TiO2, thereby shaping the potential biological outcomes. Thus, such process should be considere...
Ingested nanomaterials: impact of digestion process in the physicochemical char...
Vieira, Adriana; Vital, Nádia; Roque, Rossana; Gramacho, Ana Catarina; Rolo, Dora; Gonçalves, Lídia D.; Bettencourt, Ana; Martins, CarlaNanomaterials(NMs) provide a basis for key enabling technologies, in view of their potential to improve many products and processes, namely in food and feed industry. That is the case of titanium dioxide NMs(TiO2 NMs), presenting beneficial properties for a broad range of innovative applications such as food additives, toothpaste, pharmaceuticals, food products, etc., that may drive ingestion. The oral exposure...